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Comparison of 3 medicines oxytocin ,syntometrine and carbetocin control of post partum hemorrhage after delivery in women of reproductive age

OXYTOCIN VERSUS SYNTOMETRINE VERSUS CARBETOCIN IN CONTROL OF POST PARTUM HEMORRHAGE : AN OPEN LABEL RANDOMISED CONTROL TRIAL - nil

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/08/092610
Enrollment
158
Registered
2025-08-07
Start date
Unknown
Completion date
Unknown
Last updated
2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O721- Other immediate postpartum hemorrhage

Interventions

Intervention1: ARM 1- OXYTOCIN: OXYTOCIN IN CONTROL OF POST PARTUM HEMORRHAGE AFTER DELIVERY IN WOMEN OF REPRODUCTIVE AGE Intervention2: ARM2- SYNTOMETRINE: SYNTOMETRINE IN CONTROL OF POST PARTUM HEMO

Sponsors

NIL
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Pregnant women with singleton pregnancy of more than 28 weeks of gestation undergoing vaginal delivery or cesarean section and giving consent to participate

Exclusion criteria

Exclusion criteria: 1. Women with hypersensitivity or allergy to oxytocin , syntometrine or carbetocin. 2. Women with chronic hypertension, gestational hypertention, pre-eclampsia or ante-partum blood loss of more than 50ml. 3. Women with medical conditions like severe anemia and severe heart disease.

Design outcomes

Primary

MeasureTime frame
To compare incidence of Postpartum hemorrhage by the use of oxytocin versus syntometrine versus carbetocinTimepoint: To compare incidence of Postpartum hemorrhage by the use of oxytocin versus syntometrine versus carbetocin on day of operation and post op day 2 hemoglobin—

Secondary

MeasureTime frame
ââ?¬Â¢ To compare the intrapartum blood loss in oxytocin versus syntometrine versus carbetocin group. ââ?¬Â¢ To compare proportion of women who will require additional uterotonic drugs after administration of oxytocin versus syntometrine versus carbetocin group ââ?¬Â¢ Comparison of adverse effects (nausea, vomiting & hypotension) among oxytocin versus syntometrine versus carbetocin group.Timepoint: ââ?¬Â¢ To compare the intrapartum blood loss in oxytocin versus syntometrine versus carbetocin group. ââ?¬Â¢ To compare proportion of women who will require additional uterotonic drugs after administration of oxytocin versus syntometrine versus carbetocin group ââ?¬Â¢ Comparison of adverse effects (nausea, vomiting & hypotension) among oxytocin versus syntometrine versus carbetocin group.;ââ?¬Â¢ To compare the intrapartum blood loss in oxytocin versus syntometrine versus carbetocin group. ââ?¬Â¢ To compare proportion of women who will require additional uterotonic drugs after administration of oxytocin versus syntometrine versus carbetocin group ââ?¬Â¢ Comparison of adverse effects (nausea, vomiting and hypotension) among oxytocin versus syntometrine versus carbetocin group.Timepoint: ââ?¬Â¢ To compare the intrapartum blood loss in oxytocin versus syntometrine versus carbetocin group. ââ?¬Â¢ To compare proportion of women who will require additional uterotonic drugs after administration of oxytocin versus syntometrine versus carbetocin group ââ?¬Â¢ Comparison of adverse effects (nausea, vomiting and hypotension) among oxytocin versus syntometrine versus carbetocin group.—

Countries

India

Contacts

Public ContactDr Priyanka Garg

ALL INDIA INSTITUTE OF MEDICAL SCIENCES, BATHINDA

gkbedi17@gmail.com9464446120

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jun 11, 2026