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Comparing two different pain reducing regimens/drugs to reduce pain in patients undergoing abdominal surgery

Intraoperative Dexmedetomidine Versus Ketamine-Dexmedetomidine Infusion For Postoperative Analgesia In Major Abdominal Surgery: A Randomized Controlled Trial - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/08/092608
Enrollment
50
Registered
2025-08-07
Start date
Unknown
Completion date
Unknown
Last updated
2025-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K00-K95- Diseases of the digestive system

Interventions

Intervention1: Drug:Dexmedetomidine: Route: Intravenous Dose: 0.5mcg/kg/hr Intervention2: Drug:Dexmedetomidine with Ketamine: Route: Intravenous Dose: 0.3mcg/kg/hr and 0.3mg/kg/hr respectively Control

Sponsors

ILBS
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: ASA class 1 & 2

Exclusion criteria

Exclusion criteria: Patient refusal Contraindication to study drugs History of drug abuse Insufficient comprehension to use of PCA ASA class 3 & 4

Design outcomes

Primary

MeasureTime frame
To compare the postoperative fentanyl consumption for the first 24 hours using IV PCA in following two groups of patients undergoing major abdominal surgery Group A Intraoperative IV dexmedetomidine infusion Group B Intraoperative IV ketodex infusion Timepoint: Post Operative 24hr—

Secondary

MeasureTime frame
To compare the intraoperative anesthetic requirementsTimepoint: End of Surgery;To compare the intraoperative fentanyl requirementsTimepoint: End of surgery;To compare the postoperative pain scores using NRSTimepoint: 0,2,4,12,24hrs;To compare the time of first rescue analgesia requirementTimepoint: Post Operative;To record incidence of post operative nausea and vomitingTimepoint: Post Operative;To record incidence of post operative delirium using CAM ICU scoreTimepoint: post operative;- To compare the postoperative sedation score using the Modified Ramsay Sedation Scale(MRSS)Timepoint: postoperative;To compare the intraoperatively hemodynamic parametersTimepoint: 15mins—

Countries

India

Contacts

Public ContactDr Udit Dhingra

Institute of Liver and Biliary Sciences

uddh1989@gmail.com8861987684

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026