Health Condition 1: A499- Bacterial infection, unspecified
Conditions
Interventions
Intervention1: Active TDM Arm (Phase B): Evaluation of target concentration attainment and dose optimization on three different days in the initial 7 days of antibiotic therapy.
Control Intervention1:
Sponsors
Believers Church Medical College Hospital
Eligibility
Inclusion criteria
Inclusion criteria: Patients initiated on any one of the following antibiotics: meropenem, piperacillin, cefoperazone, ceftazidime, amikacin, gentamicin, colistin, polymyxin B, teicoplanin, vancomycin and linezolid.
Exclusion criteria
Exclusion criteria: Phase A and B Patients who will be lost to follow up within 7 days after initiating one of the above-mentioned antibiotics. Cessation of antibiotic before first sample collection for estimation of drug concentration. Patients without an arterial line on the first day of sample collection Patient continuing on empirical antibiotic without culture proven bacterial infection for 7 days. Phase B When the advice from TDM team for dose optimization is not followed in the initial 5 days of antibiotic dosing.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare clinical outcome at day 7 of antibiotic administration between patients who were dose optimized based on TDM reports for antibiotics and those who were not dose optimized based on TDM reports.Timepoint: Day 7 of antibiotic treatment | — |
Secondary
| Measure | Time frame |
|---|---|
| To study the systemic exposure to the antibiotics meropenem, piperacillin, cefoperazone, ceftazidime, amikacin, gentamicin, colistin, polymyxin B, teicoplanin, vancomycin and linezolid among the patients who receive these antibiotics on day 2/3, day 4/5 and day 6/7 from the initiation of antibiotic treatmentTimepoint: Day 2 or 3, day 4 or 5 and day 6 or 7 of antibiotic treatment;To compare the proportion of patients who develop acute kidney injury or neurotoxicity at day 7 of antibiotic administration between patients who were dose optimized based on TDM reports for antibiotics and those who were not dose optimized based on TDM reports.Timepoint: Day 7 of antibiotic treatment | — |
Countries
India
Contacts
Public ContactPhilip Mathew
Believers Church Medical College Hospital
Outcome results
None listed