Neuroprotective Effect of Ayurveda Interventions as an Add On Therapy in Primary Open Angle Glaucoma

Four Arm Randomized Controlled Trial to Evaluate the Comparative Neuroprotective Effect of Ayurveda Interventions as an Add on Therapy in Primary Open Angle Glaucoma - NIL

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/08/092590

Enrollment

100

Registered

2025-08-07

Start date

Unknown

Completion date

Unknown

Last updated

2025-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: H401- Open-angle glaucoma

Interventions

None listed

Eligibility

Inclusion criteria

Inclusion criteria: 1. Baseline IOP less than or equal to 30mmHg. 2. Newly diagnosed and untreated patients of Primary Open Angle Glaucoma. 3. Diagnosis in either or both eye with Primary Open Angle Glaucoma. 4. Glaucomatous optic disc changes with peripapillary changes having Retinal Nerve Fiber layer defects and having vertical elaborate cup disc ratio 0.5 to 0.8

Exclusion criteria

Exclusion criteria: 1. Visual acuity less than 6/60. 2. Corneal abnormalities that could preclude accurate IOP readings with NCT or applanation tonometry. 3. Patients of POAG who have media opacities which is sufficient to interfere with detailed ONH evaluation, 4. Advanced DR and HTN retinopathy 5. All types of Angle Closure Glaucoma, secondary and developmental glaucoma and end stage (advanced) glaucomatous optic neuropathy. 6. Inability to use topical medications. 7. Active treatment for another ophthalmic condition in either eye. 8. Any previous ocular surgeries except for uncomplicated cataract extraction and YAG laser capsulotomy, laser glaucoma surgeries (Argon laser trabeculoplasty and/or selective laser trabeculoplasty). 9. Pregnancy or lactating women. 10. Involvement in any other interventional research study.

Design outcomes

Primary

Measure	Time frame
Comparative neuro-protective effect of Ayurveda interventions as an add on therapy in terms of Perimetry (MD-Mean Deviation, PSD-Pattern Standard Deviation, VFI-Visual Field Index), OCT Retinal Nerve Fiber Thickness to standard of care for 30 and 90 days to conventional standard care patients of primary open angle glaucoma.Timepoint: 0 day, 30 day, 90 day	—

Secondary

Measure	Time frame
Comparative effect of Ayurveda interventions as an add on therapy on intra ocular pressure by tonometry for 30, 60 and 90 days to conventional standard care patients of primary open angle glaucoma.Timepoint: 0 day, 30 day, 60 day, 90 day	—

Countries

India

Contacts

Public ContactRamya

All India Institute of Ayurveda

hod-shalakya@aiia.gov.in9560788850

Outcome results