A randomized control trial comparing postoperative pain in patients with symptomatic irreversible pulpitis receiving a singlevisit root canal after premedication with three different antiinflammatory drugs

Comparison of Postoperative pain after Premedication with three different Anti-inflammatory Drugs in Single-visit root canal treatment for patients diagnosed with Symptomatic Irreversible Pulpitis - A Randomized Control Trial - NIL

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/08/092563

Enrollment

Registered

2025-08-06

Start date

Unknown

Completion date

Unknown

Last updated

2025-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K044- Acute apical periodontitis of pulpal origin

Interventions

Intervention1: Group 1 120 mg oral Etoricoxib Group 2 20 mg oral Piroxicam Group 3 10 mg oral Ketorolac : Each of the study group drug will be give by oral route 30 minute before the root canal tre

Eligibility

Inclusion criteria

Inclusion criteria: 1. Aged 18 to 60 will be included in the study. 2. Both male and female. 3. Systemically healthy patients (Category: American Society of Anesthesiologists class 1). 4. Single rooted tooth diagnosed with symptomatic irreversible pulpitis and symptomatic apical periodontitis. 5. Teeth will be included if they have moderate sharp spontaneous pain preoperative visual analogue scale . 6. Ability to read and comprehend the visual analogue scale sheets and informed consent 7. Teeth that demonstrated tenderness upon percussion, along with a positive reaction to electric pulp testing and a prolonged response exceeding 10 seconds to cold testing. 8. The teeth with periapical changes in radiographs . 9. Having no history of painkillers administrated with 12 hours before procedure.

Exclusion criteria

Exclusion criteria: 1. Teeth with crown/root fractures 2. Acute or chronic apical abscess 3. Pulp necrosis 4. Compromised periodontium and open apices 5. Allergic to NSAIDs 6. Pregnant or lactating women 7. Previously treated/initiated root canal treatment 8. Retreatment cases.

Design outcomes

Primary

Measure	Time frame
To assess the effect of postoperative pain after premedication with three different anti-inflammatory drugs in single-visit root canal treatment for patients diagnosed with symptomatic irreversible pulpitis.Timepoint: 6hr 12hr 24hr 48hr 72hr	—

Secondary

Measure	Time frame
To compare the effect of postoperative pain after premedication with three different anti-inflammatory drugs in single-visit root canal treatment for patients diagnosed with symptomatic irreversible pulpitis To analyse the effect of postoperative pain after premedication with three different anti-inflammatory drugs in single-visit root canal treatment for patients diagnosed with symptomatic irreversible pulpitis. Timepoint: 6hr 12hr 24hr 48hr 72hr	—

Measure

Time frame

To compare the effect of postoperative pain after premedication with three different anti-inflammatory drugs in single-visit root canal treatment for patients diagnosed with symptomatic irreversible pulpitis To analyse the effect of postoperative pain after premedication with three different anti-inflammatory drugs in single-visit root canal treatment for patients diagnosed with symptomatic irreversible pulpitis. Timepoint: 6hr 12hr 24hr 48hr 72hr

—

Countries

India

Contacts

Public ContactDr Abhay Wasu

Ranjeet Deshmukh Dental College And Research Center Nagpur

badole_g15@yahoo.co.in9665410655

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026