Comparing efficacy of oral Gabapentin and oral Clonidine as premedication on reducing postoperative pain,nausea and vomiting after general anaesthesia in Mastoidectomy surgery

Comparing effectiveness of oral Gabapentin Versus oral Clonidine as premedication on Postoperative Pain Intensity Levels and incidence of Nausea and Vomiting after General Anaesthesia in Mastoidectomy surgery - NIL

Status

Active, not recruiting

Phases

Phase 3Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/08/092522

Enrollment

100

Registered

2025-08-06

Start date

Unknown

Completion date

Unknown

Last updated

2025-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: H60-H95- Diseases of the ear and mastoid process

Interventions

Intervention1: GABAPENTIN: Gabapentin is an anticonvulsant that has antinociceptive properties. It binds the alpha 8 subunits of voltage dependent calcium ion channels and blocks the development of hy

Mitigation of tachykinin neurotransmitter activity by gabapentin has been postulated to play a role (Guttuso et al., 2003). Control Intervention1: CLONIDINE: The alpha-agonist clonidine has also shown

Quintin et al., 1991). In the study by Pandey et al. (2006) on two hundred and fifty patients scheduled for laparoscopic Cholecystectomy, gabapentin as premedication effectively suppresses nau

on Postoperative Pain Intensity Levels, incidence of nausea and vomiting in patients undergoing elective mastoidectomy surgery under gen

Eligibility

Inclusion criteria

Inclusion criteria: 1)Patient posted for Mastoidectomy surgery 2)18-60 years of age 3)ASA physical status 1&2

Exclusion criteria

Exclusion criteria: 1)Known allergy to gabapentin and clonidine 2)Patient refusal 3)Pregnant and lactating women

Design outcomes

Primary

Measure	Time frame
To assess the post operative pain intensity levels between the oral clonidine and oral gabapentin groupsTimepoint: First 12 hours postoperatively	—

Secondary

Measure	Time frame
To assess the incidence of postoperative nausea & vomiting between the two groupsTimepoint: First 12 hours postoperatively	—

Countries

India

Contacts

Public ContactDr Vimal M

ESIC Medical College

radhikamurali0095@gmail.com9840170887

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026