A study comparing the effects on heart rate and blood pressure when using two different medicines 4 percentage lignocaine and 1 microgram per kg dexmedetomidine given as a mist through a mask before inserting a breathing tube

Comparison of hemodynamic changes after nebulization with 4 percentage lignocaine and with 1 microgram per kg dexmedetomidine for endotracheal intubation - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/08/092488

Enrollment

104

Registered

2025-08-06

Start date

Unknown

Completion date

Unknown

Last updated

2025-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: nebulization with 4% lignocaine and with 1 mcg/ kg dexmedetomidine prior to endotracheal intubation: Nebulization will be started 30 minutes before induction of anaesthesia, nebulizatio

Eligibility

Inclusion criteria

Inclusion criteria: American Society of Anaesthesiologists (ASA) Status I and II Patients undergoing elective surgery requiring general anaesthesia with endotracheal intubation

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

Measure	Time frame
To observe the effect of nebulization of 4% Lignocaine and nebulization of 1 mcg/kg dexmedetomidine on heart rate and blood pressure after endotracheal intubation with C Mac D blade videolaryngoscopy Timepoint: baseline, after nebulization, after induction, post-intubation at 1, 5 and 10 min (T1, T5 and T10) and 2 hr postsurgery	—

Secondary

Measure	Time frame
To observe the effect of nebulization of 4% Lignocaine and nebulization of 1 mcg/kg dexmedetomidine on postoperative sore throat after endotracheal intubation with C Mac D blade videolaryngoscopyTimepoint: Postoperatively, an independent observer blinded to the allocation group will assess the patient for postoperative pain and sore throat at 2-hr post-surgery, when patients will be recovered from the effects of anaesthetic agents	—

Measure

Time frame

To observe the effect of nebulization of 4% Lignocaine and nebulization of 1 mcg/kg dexmedetomidine on postoperative sore throat after endotracheal intubation with C Mac D blade videolaryngoscopyTimepoint: Postoperatively, an independent observer blinded to the allocation group will assess the patient for postoperative pain and sore throat at 2-hr post-surgery, when patients will be recovered from the effects of anaesthetic agents

—

Countries

India

Contacts

Public ContactDr Dheeraj Kapoor

Government Medical College and Hospital,Chandigarh

manpreetdawar@gmail.com9646121503

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026