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A study to assess two materials [1.enamel-based gel(synthetic), 2.platelet-rich injection (derived from 10ml of patients blood)] in the treatment of gum infections in patients with gum disease

Comparison Of Enamel Matrix Derivative and Injectable Platelet Rich Fibrin as an adjunct to Non-Surgical Periodontal Therapy: A Randomized Control Trial - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/08/092469
Enrollment
45
Registered
2025-08-06
Start date
Unknown
Completion date
Unknown
Last updated
2026-06-01

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K053- Chronic periodontitis

Interventions

Intervention1: Enamel matrix derivative (Struamann Emdogain®): Scaling and root planing with Struamann Emdogain® 1.5 ml- single injection, through gingival sulcus, for a duration of 60 seconds. Int

Sponsors

Dr Madhumitha S
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients with Stage II/III periodontitis- CAL of 5-8 mm with PPD of 5-8 mm, Interdental vertical defects detected by radiovisiographs.

Exclusion criteria

Exclusion criteria: Patients who are systemically compromised, Patients who are smokers, Pregnant and lactating women, Subjects who had undergone periodontal therapy in the past 3 months, Subjects who were under antibiotic therapy in the past 3 months, Patients with metabolic diseases related to bone, Subjects on drugs that might alter bone metabolism.

Design outcomes

Primary

MeasureTime frame
Mean clinical attachment level Mean probing pocket depth Mean gingival index Mean plaque index Mean bone fill Mean alkaline phosphatase level in gingival crevicular fluid Timepoint: Baseline, 15th day, 60th day, 3rd month, 6th month

Secondary

MeasureTime frame
NILTimepoint: NIL

Countries

India

Contacts

Public ContactDr Saravana Kumar R

Indira Gandhi Institute of Dental Sciences, SBV, Pondicherry

pratebhabalu@igids.ac.in9894360543

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Jun 11, 2026