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Exploring the Effects of Gum Treatment on Iron and Inflammation in the Body

ESTIMATION OF THE EFFECT OF NONSURGICAL PERIODONTAL THERAPY ON HEPCIDIN, INFLAMMATORY AND IRON MARKER LEVELS AN INTERVENTIONAl STUDY - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/08/092427
Enrollment
58
Registered
2025-08-05
Start date
Unknown
Completion date
Unknown
Last updated
2025-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Non-Surgical Periodontal Therapy: it involves scaling with ultrasonic scalers and root planing with area-specific Gracey curettes, aiming to remove the granulation tissue, which aids in

Sponsors

NIL
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. 30-65 years of age. 2. Patients with only periodontitis and with no other systemic diseases. 3. Patients with no tooth loss; CAL 1 to 4 mm; PD less than or equal to 5 mm will be considered as Group 1, less than or equal to 5 teeth lost due to periodontitis, CAL greater than or equal to 5 mm, and PD greater than or equal to 6mm will be considered as Group 2.

Exclusion criteria

Exclusion criteria: 1. Pregnant and lactating women. 2. Systemically compromised patients. 3. No past history of smoking. 4. Patients under antibiotic drug therapy. 5. Patients under orthodontic treatment. 6. Patients with a history of steroid and nonsteroidal anti-inflammatory drugs. 7. Patients undergoing iron replacement therapy for anemia. 8. Patients who underwent subgingival scaling and periodontal surgery at least 6 months prior.

Design outcomes

Primary

MeasureTime frame
1. serum hepcidin 2. pro-inflammatory cytokines : IL-1Beta, hs-CRP, ESR 3. iron markers : Serum iron, transferrin saturation receptor, ferritinTimepoint: 20 days

Secondary

MeasureTime frame
nilTimepoint: nil

Countries

India

Contacts

Public ContactPutta Uday Simha

NITTE University

bhandaryrahul@gmail.com9845583085

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026