Health Condition 1: O- Medical and Surgical
Conditions
Interventions
Intervention1: nil: nil
Control Intervention1: Group F : Fixed dose group: will receive weight based dose of muscle relaxant atracurium with fixed dose of neostigmine
Control Intervention2: Group Va
Sponsors
Singam Geetha
Eligibility
Inclusion criteria
Inclusion criteria: ASA 1-2 , 18-65 yr age, both gender, BMI :18.5 to 27 kg/m2, Duration of surgery: 1hr to 3 hr Elective surgery
Exclusion criteria
Exclusion criteria: A history of myopathy, polyneuropathy, Severe kidney or liver diseases, Thyroid disorders, Myasthenia or stroke, Patients treated with amino glycosides or magnesium or any medication known to influence neuromuscular function, Unexpected difficult airway, Pregnancy, breastfeeding, Emergency surgery, Chronic obstructive pulmonary disease, CAD, Electrolyte imbalance, Intra operative airway complication-bronchospasm and aspiration
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1.Feasibility of providing adequate surgical conditions by maintaining entropy of 40-50 and without dense neuromuscular blockade. 2.Comparison of surgical conditions and atracurium requirement between use of liberal dose of atracurium to achieve dense neuromuscular block (group F) and restricted use of atracurium while maintain adequate depth of anesthesia (group V) 3.Comparison of dose of neostigmine for reversal of NMBD with a liberal dose of neostigmine administered based on clinical judgment with administration of neostigmine titrated to TOF ratio. Timepoint: intraop | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Comparison of maximum intra abdominal pressure, peak airway pressure at highest intra abdominal pressure, airway Compliance at highest intra abdominal pressure, requirement of isoflurane, requirement of intraoperative fentanyl between the groups. 2. Comparison of TOF ratio at the time of decision of reversal and time for extubation, 3. Comparison of TOF ratio at extubation and in the post extubation period, 4. Comparison of postoperative pulmonary complications between the groups, 5. Comparison of VAS and RSS score between the groups, 6. Comparison of change in muscle grip strength and PEFR from baseline, time required to sit and stand between the groups. Timepoint: Intraop, postop 15min,1hr,,3hr and 24 hr | — |
Countries
India
Contacts
Public ContactSingam Geetha
Nizams Institute of Medical Sciences
Outcome results
None listed