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Effect of ondansetron on spinal anesthesia induced low blood pressure and low heart rate in individuals undergoing lower limb and lower abdominal surgeries

Effects of ondansetron on subarachnoid block induced hypotension and bradycardia in lower abdominal and lower limb surgeries - Nil

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/08/092418
Enrollment
190
Registered
2025-08-05
Start date
Unknown
Completion date
Unknown
Last updated
2025-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: PCS-

Interventions

Intervention1: Inj Ondansetron 0.15mg/kg diluted in 10ml normal saline: In group A Inj Ondansetron 0.15mg/kg will be administered diluted in 10ml normal saline Control Intervention1: Inj 10ml normal

Sponsors

Shri Ram Murti Smarak Institute of Medical Sciences
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients with ASA grade I and II Patients of age group between 18-60 years Patients posted for elective surgery under spinal anaesthesia

Exclusion criteria

Exclusion criteria: Patients with contraindications to spinal anaesthesia Patients allergic to study drugs History of hypertension, coronary artery disease Morbidly obese patients Patients using prophylactic or therapeutic anticoagulation treatments Patients taking selective serotonin reuptake inhibitors or migraine medications Patient s refusal

Design outcomes

Primary

MeasureTime frame
The primary outcome measure of our study is to evaluate the effect of ondansetron on hemodynamic stability after subarachnoid block for lower abdominal and lower limb surgeriesTimepoint: Hemodynamic parameters HR SBP DBP MAP and SpO2 will be recorded at baseline than after every 3 minutes for 15 minutes every 5 minutes till end of surgery and then every 30 minutes for next 2 hours in post-operative room—

Secondary

MeasureTime frame
The secondary outcome measure of our study is to compare the effect of ondansetron group with the placebo groupTimepoint: Hemodynamic parameters HR SBP DBP MAP and SpO2 will be recorded at baseline than after every 3 minutes for 15 minutes every 5 minutes till end of surgery and then every 30 minutes for next 2 hours in post-operative room—

Countries

India

Contacts

Public ContactDr Dheeraj Saxena

Srms ims bareilly

drsdheeraj@gmail.com9557230046

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026