Health Condition 1: K70-K77- Diseases of liver
Conditions
Interventions
Intervention1: Oral pentoxiphylline 400 mg thrice daily: Oral pentoxiphylline will be started 3 days prior to Liver transplantation and continued till postoperative day 7
Control Intervention1: Placeb
Sponsors
Dr Rela Institute and Medical centre
Eligibility
Inclusion criteria
Inclusion criteria: all Living donor liver transplant recipients with an expected graft recipient weight ratio less than 0.8
Exclusion criteria
Exclusion criteria: Unwilling for participation, acute liver failure and acute on chronic liver failure, MELD score more than 30, chronic kidney disease, cardiac dysfunction such as arrhythmia, heart blocks and coronary artery disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| the liver regeneration at POD 8 which will measured by non-contrast three-dimensional computed tomography/magnetic resonance imagingTimepoint: till 8 th postoperative day | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Assessment of the incidence of small for size syndrome 2. Assessment of degree of postoperative liver injury by daily measurement of postoperative serum transaminases, bilirubin and prothrombin time (PT)/international normalized ratio (INR) until POD 7 3. Assessment of other recovery parameters such as length of ICU and hospital stay, Clavien Dindo classification of surgical complications 4. Assessment of adverse drug events directly attributable to the PTXTimepoint: till 8th postoperative day | — |
Countries
India
Contacts
Public ContactSusan Paulin
Dr Rela Institute And Medical Centre
Outcome results
None listed