A Study Comparing Normal Saline, 2 percentage lignocaine, and 0.75 percentage Ropivacaine for Cuff Inflation in Reducing Sore Throat After General Anaesthesia with Breathing Tube (Endotracheal Intubation)

Effect of intracuff Inflation with Normal Saline versus 2 percentage Lignocaine versus 0.75 percentage Ropivacaine on the incidence of Post-Operative Sore Throat in patients undergoing General Anaesthesia with Endotracheal intubation - A Randomized Controlled Trial.

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/08/092370

Enrollment

120

Registered

2025-08-05

Start date

Unknown

Completion date

Unknown

Last updated

2025-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Intracuff inflation of Local anaesthesia (2 percentage lignocaine,0.75 percentage Ropivacaine): Intracuff inflation of single administration of lignocaine and ropivacaine before inducti

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients scheduled for elective surgeries under General Anaesthesia with endotracheal intubation 2. Aged between 18 and 65 years of either gender 3. Belonging to ASA Physical status I & II (American society of Anaesthesiologists Physical Status)

Exclusion criteria

Exclusion criteria: 1. Allergic to local anaesthetics 2. Anticipated difficult airway 3. Undergoing oral, head and neck surgeries 4. Surgeries in prone position 5. Patients with acute/ chronic respiratory diseases and active smoking at present. 6. Pregnant females 7 Patient on chronic pain medications

Design outcomes

Primary

Measure	Time frame
incidence of post operative sore throat .Timepoint: sore throat measured at the 0,2,4,6,8,24hours of end of surgery	—

Secondary

Measure	Time frame
to compare the incidence of postoperative cough and hoarsness of voice ,other airway related complications.Timepoint: measured at the end of 0,2,4,6,8,24 hours of surgery	—

Countries

India

Contacts

Public ContactPRADEEP P

pondicherry institute of medical science

Siva85dr@gmail.com9944060676

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026