Comparing how well three different treatments work in reducing pain, swelling, and discomfort after wisdom tooth removal: cold saline rinses, regular saline rinses combined with oral enzyme tablets, and regular saline rinses combined with an anti-inflammatory injection under the gum.

COMPARISON OF EFFICACY OF COLD SALINE IRRIGATION, NORMAL SALINE IRRIGATION WITH ORAL ENZYME PREPARATION AND NORMAL SALINE IRRIGATION WITH SUBMUCOSAL DEXAMETHASONE INFILTRATION ON POST OPERATIVE SYMPTOMS AFTER SURGICAL REMOVAL OF IMPACTED MANDIBULAR THIRD MOLAR - A RANDOMIZED CONTROLLED TRIAL - NIL

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/08/092346

Enrollment

Registered

2025-08-04

Start date

Unknown

Completion date

Unknown

Last updated

2025-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K011- Impacted teeth

Interventions

Intervention1: Normal Saline Irrigation With Oral Enzyme Preparation: Irrigation of Extraction Socket with Normal Saline Followed by Prescribing Oral Enzyme Preparation After Closure of Extraction Soc

Eligibility

Inclusion criteria

Inclusion criteria: 1) pt belonging to the age group of 18-40 years . 2) pt who have not used any antibiotic, anti-inflammatory 1 week before the surgery 3)pt with mild to moderate surgical difficulty on evaluation according to Pederson difficulty index score 3-4 and 5-7 4) pt with normal bleeding and clotting time 5) pt who are non smokers 6)pt with ASA 1 category 7) pt having indication for extraction of impacted mandibular third molar

Exclusion criteria

Exclusion criteria: 1) pt who are not willing to participate or take part in the study. 2) pt with previous allergies to anaesthetic agents used. 3) pregnant or lactating female patients. 4) pt who are immunocompromised or suffering from any systemic conditions. 5)pt having bacterial and fungal infection 6) pt allergic to corticosteroids. 7) pt on anticoagulant drugs

Design outcomes

Primary

Measure	Time frame
Post operative swellingTimepoint: 3rd and 7th day	—

Secondary

Measure	Time frame
Post operative painTimepoint: 3rd & 7th day;Post operative trismusTimepoint: 3rd & 7th day	—

Countries

India

Contacts

Public ContactDR SD Baliga

DEPARTMENT OF ORAL AND MAXILLOFACIAL SURGERY KLE VK INSTITUTE OF DENTAL SCIENCES, BELAGAVI

rishaby14@gmail.com9967970913

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026