Health Condition 1: O- Medical and Surgical
Conditions
Interventions
Intervention1: fentanyl: patients will receive an intravenous bolus injection of fentanyl 2 microgram per kg f/b infusion at 1 microgram per kg per hour. repeat dose of fentanyl 10 microgram intraveno
Sponsors
School of Medical Sciences and Research Sharda university
Eligibility
Inclusion criteria
Inclusion criteria: patient scheduled for laparoscopic cholecystectomy age between 18 to 60 years ASA grade I and II both genders duration of surgery less than and equal to two hours
Exclusion criteria
Exclusion criteria: BMI more than 30 kg per meter square Patient having history of drug allergy to ketamine and lidocaine and Magnesium Sulphate. History of chronic usage of opioids and any other analgesics. Pregnant females History of psychiatric illness. History of endocrine disease example diabetes mellitus and thyroid disease. History of CNS or Cardiovascular and renal disease.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To evaluate and compare the intraoperative anti nociception efficacy with opioid versus opioid free anaesthesia (Ketamine, lidocaine and Magnesium sulphate) by change in SPI in response to surgical noxious stimulation following skin incision till 24 hours.Timepoint: To evaluate and compare the intraoperative anti nociception efficacy with opioid versus opioid free anaesthesia (Ketamine, lidocaine and Magnesium sulphate) by change in SPI in response to surgical noxious stimulation following skin incision till 24 hours. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1) To evaluate & compare the intraoperative anti-nociception efficacy with opioid (fentanyl) versus opioid free anaesthesia (Ketamine, lidocaine & Magnesium sulphate) with regard to:- a) SPI (before & after intubation, before skin incision, before & after skin closure, before & after extubation) b) HR, MAP, Lacrimation, sweating (before & after intubation, skin incision, skin closure & extubation)Timepoint: peri operative monitoring till 24 hours post operatively;To evaluate & compare opioid (fentanyl) versus opioid free anaesthesia (Ketamine, lidocaine & Magnesium sulphate) with regard to:- a) Duration of Postoperative analgesia & pain severity b) Incidence of Postoperative Nausea & Vomiting c) Duration of discharge from Post Anaesthetic Care Unit d) Post operative assessment of awarness e) Total consumption of propofol, fentanyl, cis-atracurium, ketamine, lidocaine & magnesium sulphate.Timepoint: peri operative till post operative 24 hours. | — |
Countries
India
Contacts
Public ContactDr UC Verma
school of medical sciences and research sharda university
Outcome results
None listed