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A Study on the Effectiveness of Chitosan Nanoparticles in Healing Decayed Primary Molars in Children

A Randomized Controlled Trial to evaluate the efficacy of chitosan nanoparticle as a vehicle in lesion sterilisation and tissue repair(LSTR) in primary molars - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/08/092285
Enrollment
82
Registered
2025-08-04
Start date
Unknown
Completion date
Unknown
Last updated
2025-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: R00-R99- Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified

Interventions

Intervention1: TRIPLE ANTIBIOTIC PASTE WITH CHITOSAN NANOPARTICLE: The intervention group will receive chitosan nanoparticle as a vehicle for triple antibiotic paste in LSTR, utilizing chitosan s stro

Sponsors

DRSREELAKSHMI JAYALAL
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Clinical features 1.Children aged: 6- 12 years 2. Children with deep caries approximating pulp in primary molars. 3. Presence of gingival abscesses, fistula opening 4. Tooth showing one or more signs and symptoms such as pain, tender to percussion, mobility (grade I, II) 5. Pulpotomized tooth failure Radiographical features 1. Furcation, or periapical radiolucency 2. Evidence of pathologic external or internal root resorption with atleast two- thirds of the root 3. Coronal deep carious lesion involving or approximating pulp 4. Radicular - discontinuity of lamina dura

Exclusion criteria

Exclusion criteria: Clinical features 1. Non restorable tooth 2. Patients with medical problems, systemic diseases or drug allergy 3. Special children with a physical or emotional alteration 4. Caries in primary teeth exhibiting pre-shedding mobility or nearing exfoliation Radiographical features 1. Evidence of excessive internal or external root resorption involving more than half of the root 2. Perforated pulpal floor 3. excessive bone loss in furcation area involving underlying tooth germ

Design outcomes

Primary

MeasureTime frame
Publication in PubMed/Scopus/Web of Science Patent Start-up Entrepreneurship potential Preliminary study for Extra-mural GrantTimepoint: 1. Sample collection/ testing of samples: 1 year 2. Follow up: 0 month,3rd month,6th month 3. Result compilation & Statistical Analysis: 16th month 4. Manuscript Completion: 17th month 5. Publication process start: 18th month

Secondary

MeasureTime frame
NilTimepoint: Nil

Countries

India

Contacts

Public ContactDR NIDHI GUPTA

Santosh Dental College Santosh Deemed to be University

nid_gup6@yahoo.co.in9810358916

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026