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Comparing Magnesium and Ketamine to Prevent Muscle Twitches and Pain After Succinylcholine in Patients Undergoing Surgery

Comparison of Prophylactic Intravenous magnesium versus ketamine on Succinylcholine-Induced Fasciculations and Postoperative Myalgia in Patients Undergoing Elective Surgery under General Anaesthesia - Nil

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/08/092279
Enrollment
128
Registered
2025-08-04
Start date
Unknown
Completion date
Unknown
Last updated
2025-09-15

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Intravenous Magnesium Sulphate (40 mg/kg): Group A - 64 subjects will be administered with 40 mg/kg magnesium sulphate in 100 ml NS, infused in 10 minutes. Control Intervention1: Intrav

Sponsors

SRMS IMS
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: ASA physical status I/II. Patients undergoing elective surgery under general anaesthesia.

Exclusion criteria

Exclusion criteria: Pregnancy Emergency cases Contraindication to succinylcholine History of neuromuscular disease Patients taking calcium channel blockers, B blockers Systemic disease HTN, DM Substance abuse Hyperkalemia Allergic to study drugs. Patients requiring post operative ICU ventilation.

Design outcomes

Primary

MeasureTime frame
To evaluate the effect of intravenous magnesium sulphate on succinylcholine - induced fasciculations and postoperative myalgia in patients undergoing elective surgery under general anesthesia. To evaluate the efficacy of intravenous ketamine on succinylcholine - induced fasciculations and postoperative myalgia in patients undergoing elective surgery under general anesthesia.Timepoint: The incidence and severity of succinylcholine induced fasiculations will be observed soon after its administeration and postoperative myalgia will be determined at 0 hour, 6 hour, 12 hour, 24 hour, and 48 hour.—

Secondary

MeasureTime frame
To compare the effect of intravenous magnesium sulphate and ketamine in succinylcholine - induced fasciculations and postoperative myalgia. To observe the adverse effect associated with the study drugs.Timepoint: The incidence and severity of succinylcholine induced fasiculations will be observed soon after its administeration and postoperative myalgia will be determined at 0 hour, 6 hour, 12 hour, 24 hour, and 48 hour.—

Countries

India

Contacts

Public ContactDr Ashita Mowar

Department of Anaesthesia , Shri Ram Murti Smarak Institute of Medical Sciences (SRMS IMS)

drash.royals@gmail.com9568578724

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026