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Studying nitrofurantoin and silver impregnated nitrofurantoin affecting pain and healing after root canal treatment: A clinical trial

Evaluating Intracanal Medicaments: Nitrofurantoin, Nano-Silver Nitrofurantoin, and Ultracal in Postoperative Pain and Periapical Lesion Management - A Randomized Trial - NIL

Status
Active, not recruiting
Phases
Phase 4
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/08/092269
Enrollment
66
Registered
2025-08-04
Start date
Unknown
Completion date
Unknown
Last updated
2025-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K041- Necrosis of pulp

Interventions

Intervention1: Nitrofurantoin impregnated silver nanoparticles as an intracanal medicament: After biomechanical preparation 25mg nitrofurantoin impregnated silver nanoparticles 1:1 ratio is placed as

Sponsors

Dr Kalp R Kubadiya
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients between the age group of 18 60 years. Physically and mentally healthy patients. Maxillary and mandibular single-rooted teeth. Clinically negative response or no tenderness on percussion. No response on cold and EPT pulp sensitivity testing. Patients Diagnosed with symptomatic apical periodontitis. Radiographically presence of periapical radiolucency of 2-5 mm size. Patients who gave consent for treatment and follow-up. Patients who were ready to participate in the study.

Exclusion criteria

Exclusion criteria: Systemically compromised patients. Multirooted tooth. Weeping canal Positive history of antibiotics and analgesics use within the week before treatment. Large periapical lesion Retreatment cases Patients taking antibiotics or immunosuppressive drugs six months before the study. Pregnancy or lactation

Design outcomes

Primary

MeasureTime frame
Reduction of post operative pain and resolution of periapical abscessTimepoint: 1 year

Secondary

MeasureTime frame
Time required for the resolution of the lesion to interpret the effectiveness of the treatmentTimepoint: 1 year

Countries

India

Contacts

Public ContactDr Leena Jobanputra

Government Dental College and Hospital Jamnagar

lihiren@yahoo.com9879503545

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026