The power of vitamins D and K - enhancing bone health around dental implants

To explore the synergistic influence of vitamin D and vitamin K and its supplementation on bone remodeling process in conventional dental implants an interventional study - NIL

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/08/092142

Enrollment

Registered

2025-08-01

Start date

Unknown

Completion date

Unknown

Last updated

2025-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: M267- Dental alveolar anomalies

Interventions

Intervention1: Vitamin D and Vitamin K supplementation: To optimize conditions for dental implant placement, each patients serum 25-hydroxy vitamin D levels will be measured beforehand. If levels are

Eligibility

Inclusion criteria

Inclusion criteria: Patients who have edentulous areas in either the mandibular or maxillary region, or both, are suitable candidates for implant-based rehabilitation.

Exclusion criteria

Exclusion criteria: 1. Any systemic or debilitating illness that impacts bone health (e.g., uncontrolled diabetes mellitus, osteoporosis) 2. Pregnant, lactating, and post-menopausal females. 3. History of radiation to head and neck. 4. Patients requiring ridge augmentation procedures. 5. Individuals who regularly use anti-inflammatory medication and steroids. 6. Regular intake of any medication that impacts on bone metabolism. (e.g., Anti-convulsants, opioids, anti-depressants)

Design outcomes

Primary

Measure	Time frame
Radiographic parameter through1. Orthopantomography (OPG) 2.Cone beam computed tomography (CBCT) to assess a. Type of the bone b.Bone Mineral Density c.Crestal bone loss Biochemical analysis 1.Serum 25-hydroxy vitamin D levels 2.Serum vitamin K levels 3.Peri-implant sulcular fluid Osteocalcin level Timepoint: The study evaluated clinical, radiographic, and peri-implant sulcular fluid osteocalcin parameters at baseline (7 days post-implant), 1 month, and 3 months. Serum 25-hydroxyvitamin D and vitamin K levels were assessed prior to implant placement. In patients with vitamin D deficiency, serum levels were reassessed after supplementation before implant placement. Serum vitamin K levels were also reassessed at 3 months post-implant placement.	—

Measure

Time frame

Radiographic parameter through1. Orthopantomography (OPG) 2.Cone beam computed tomography (CBCT) to assess a. Type of the bone b.Bone Mineral Density c.Crestal bone loss Biochemical analysis 1.Serum 25-hydroxy vitamin D levels 2.Serum vitamin K levels 3.Peri-implant sulcular fluid Osteocalcin level Timepoint: The study evaluated clinical, radiographic, and peri-implant sulcular fluid osteocalcin parameters at baseline (7 days post-implant), 1 month, and 3 months. Serum 25-hydroxyvitamin D and vitamin K levels were assessed prior to implant placement. In patients with vitamin D deficiency, serum levels were reassessed after supplementation before implant placement. Serum vitamin K levels were also reassessed at 3 months post-implant placement.

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Secondary

Measure	Time frame
1. Plaque Index -Turesky Gilmore Glickman modification of Quigley Hein Plaque Index 1970 2. Gingival index - Loe & Silness 1963 3. Gingival phenotype Based on transparency of the periodontal probe through gingival margin. 4. Width of keratinized mucosa 5. Full - mouth Periodontal Probing depth Measurements will be recorded using manual UNC 15 periodontal probe Timepoint: 7th day as baseline after implant placement, 1 month & 3 months post implant placement;1. Plaque Index - Turesky Gilmore Glickman modification of Quigley Hein Plaque Index 1970 2. Gingival index - Loe & Silness 1963 3. Gingival phenotype Based on transparency of the periodontal probe through gingival margin. 4. Width of keratinized mucosa 5. Full - mouth Periodontal Probing depth Measurements will be recorded using manual UNC 15 periodontal probe Timepoint: 7th day as baseline after implant placement, 1 month & 3 months post implant placement	—

Measure

Time frame

1. Plaque Index -Turesky Gilmore Glickman modification of Quigley Hein Plaque Index 1970 2. Gingival index - Loe & Silness 1963 3. Gingival phenotype Based on transparency of the periodontal probe through gingival margin. 4. Width of keratinized mucosa 5. Full - mouth Periodontal Probing depth Measurements will be recorded using manual UNC 15 periodontal probe Timepoint: 7th day as baseline after implant placement, 1 month & 3 months post implant placement;1. Plaque Index - Turesky Gilmore Glickman modification of Quigley Hein Plaque Index 1970 2. Gingival index - Loe & Silness 1963 3. Gingival phenotype Based on transparency of the periodontal probe through gingival margin. 4. Width of keratinized mucosa 5. Full - mouth Periodontal Probing depth Measurements will be recorded using manual UNC 15 periodontal probe Timepoint: 7th day as baseline after implant placement, 1 month & 3 months post implant placement

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Countries

India

Contacts

Public ContactDR BHOOMIKA T M

BANGALORE INSTITUTE OF DENTAL SCIENCES

bhoomika.talad@gmail.com7899846440

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026