Comparison of lignocaine, labetalol and esmolol for blunting of the physiological changes seen during laryngoscopy and intubation under general anaesthesia, i.e. rise in blood pressure, heart rate, and serum cortisol levels.

Comparison of intravenous lignocaine, esmolol and labetalol for attenuation of hemodynamic and stress response to laryngoscopy and endotracheal intubation under general anaesthesia. - NIL

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/07/092130

Enrollment

105

Registered

2025-07-31

Start date

Unknown

Completion date

Unknown

Last updated

2025-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: - Health Condition 2: O- Medical and Surgical

Interventions

Intervention1: Nil: Nil Control Intervention1: Intravenous lignocaine: Intravenous lignocaine compared to esmolol and labetalol for attenuation of hemodynamic and stress response to laryngoscopy and e

Eligibility

Inclusion criteria

Inclusion criteria: 1. ASA Grade I and II 2. Elective surgical procedure

Exclusion criteria

Exclusion criteria: 1. Known sensitivity to any drug. 2. Pregnant females. 3. Patient with chronic hypertension and diabetes mellitus. 4. Patient with history of cardiac or respiratory disease. 5. Patient with anticipated difficult airway. 6. Patient with impaired kidney or liver function.

Design outcomes

Primary

Measure	Time frame
Haemodynamic parameters to laryngoscopy and endotracheal intubation (heart rate, systolic blood pressure, diastolic blood pressure, and mean arterial pressure)Timepoint: On arrival to OT, on laryngoscopy and intubation at 1 minute, 3 minutes and 5 minutes.	—

Secondary

Measure	Time frame
Biochemical markers of stress response (serum cortisol and blood glucose levels).Timepoint: At arrival in OT, 5 minutes after endotracheal intubation.	—

Countries

India

Contacts

Public ContactLalita Chaudhary

ABVIMS and Dr. Ram manohar lohia hospital, New Delhi

lalitachaudhary055@gmail.com9968299710

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026