A randomised study comparing clonidine and adrenaline added to lignocaine for blood pressure stability and pain relief during lower molar tooth extraction.

Comparing clonidine-enhanced lignocaine and adrenaline-enhanced lignocaine for hemodynamic stability and analgesic outcomes in mandibular molar extractions- A randomised controlled trial - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/07/092118

Enrollment

Registered

2025-07-31

Start date

Unknown

Completion date

Unknown

Last updated

2025-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Lignocaine with clonidine: Clonidine will be given with lignocaine to cause vasoconstriction without increasing the blood pressure. Control Intervention1: Lignocaine with Adrenaline: Li

Eligibility

Inclusion criteria

Inclusion criteria: 1.Age 20 60 years 2.ASA (American Society of Anaesthesiologists) physical status I and II 3.No known allergies to lignocaine, clonidine, or adrenaline 4.Presence of dental caries, periapical abscess, or periodontitis requiring extraction 5.Simple, non-complicated extractions

Exclusion criteria

Exclusion criteria: 1.Patients on medications that may affect healing (e.g., steroids, anticoagulants) 2.Pregnant or lactating women 3.Patients with bleeding disorders or previous history of extractions 4.Patients with impacted or submerged teeth 5.Patients with a history of smoking, alcohol consumption, or substance abuse. 6.Impacted and unerupted tooth

Design outcomes

Primary

Measure	Time frame
Time of onset and duration of action - In this, we will assess the time of onset of a drug and how long it takes to start working after administration and assess the duration of action of drug, which refers to the effectiveness of the drug in the body after administration. Hemodynamic parameters (Blood Pressure, Mean Arterial Pressure) will be assessed by Digital Sphygmomanometer Heart Rate and SpO: will be assessed by pulse oximeter.Timepoint: 10 min before anaesthesia,10 min after anaesthesia,30 min after surgical procedure	—

Measure

Time frame

Time of onset and duration of action - In this, we will assess the time of onset of a drug and how long it takes to start working after administration and assess the duration of action of drug, which refers to the effectiveness of the drug in the body after administration. Hemodynamic parameters (Blood Pressure, Mean Arterial Pressure) will be assessed by Digital Sphygmomanometer Heart Rate and SpO: will be assessed by pulse oximeter.Timepoint: 10 min before anaesthesia,10 min after anaesthesia,30 min after surgical procedure

—

Secondary

Measure	Time frame
Post Operative Rescue Analgesics- Time until the initial dose of rescue analgesic following the administration of local anaesthetic. Patient-reported pain scores (VAS scale)- The Visual Analog Scale (VAS) is a simple, continuous measurement tool used to assess subjective experiences like pain or emotions.Timepoint: Within 24 hours	—

Countries

India

Contacts

Public ContactDR AKHOURI PRAKHAR SINHA

KOTHIWAL DENTAL COLLEGE AND RESEARCH CENTRE

drakhouriprakhar@gmail.com6386046351

Outcome results