Which Works Better for Depression? A Study of Escitalopram vs Desvenlafaxine

Comparison Of Efficacy and Safety of Escitalopram Versus Desvenlafaxine In Major Depressive Disorder In a Tertiary Care Hospital: A Prospective Randomised Open Label Study.

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/07/092082

Enrollment

100

Registered

2025-07-31

Start date

Unknown

Completion date

Unknown

Last updated

2025-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: F329- Major depressive disorder, singleepisode, unspecified

Interventions

Intervention1: Tab Escitalopram 10mg: Tab Escitalopram 10mg HS orally after food for 12 weeks. Control Intervention1: Tab Desvenlafaxine 100mg: Tab Desvenlafaxine 100mg HS orally after food for 12 wee

Eligibility

Inclusion criteria

Inclusion criteria: Drug naive patients diagnosed with major depression and started with antidepressants in outpatient of department of psychiatry. Patients who are willing to give informed consent.

Exclusion criteria

Exclusion criteria: Age: LESS THAN 18 AND MORE THAN 60yrs Patients with Bipolar depression. Patients who are not willing to give informed consent. Uncooperative patients

Design outcomes

Primary

Measure	Time frame
To compare and assess the efficacy of escitalopram versus Desvenlafaxine in treating major depressive disorderTimepoint: 0,4,8,12 weeks	—

Secondary

Measure	Time frame
To compare and assess the safety of escitalopram versus Desvenlafaxine in treating major depressive disorderTimepoint: 0,4,8,12 weeks	—

Countries

India

Contacts

Public ContactDr Vandana Badar

IGGMC Nagpur

drvandanabadar@gmail.com9960031486

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026