Health Condition 1: M628- Other specified disorders of muscle
Conditions
Interventions
Intervention1: YI: Yogic intervention: The proposed yogic intervention involves a 45-minute session of low to moderate intensity yoga
practices including physical postures(padmasadhana series), breath
Sponsors
AIIMS Rishikesh
Eligibility
Inclusion criteria
Inclusion criteria: 1. Age Group/Gender- 60 to 70 yr, Male & Female 2. Having SARC-F score greater or equal to 4 (possible sarcopenia) and sarcopenia, as per the AWGS 2019 community guidelines 3. Subjects practicing less than 150 min. of exercise per week 4. Willing to comply with the study procedures and provide a written informed consent
Exclusion criteria
Exclusion criteria: 1. Known cases of chronic kidney disease, chronic liver disease, primary malignancy, osteoarthritis, uncontrolled diabetes ,uncontrolled hypertension, HIV, on ICD and stroke. 2. Diagnosed cases of psychiatric disorders like severe depression, schizophrenia. 3. Active infections or sepsis. 4. Recent trauma, fractures, major surgeries (CABG, lower limb hip or knee replacement, renal transplants ), musculoskeletal pains or any dysfunction that prevents physical activity. 5. Subjects on anabolic steroids, glucocorticoids, chemotherapy, antituberculosis drugs and thyroxine.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Physical Performance Evaluated by Short Physical Performance Battery (SPPB)Timepoint: Day 0 (baseline), Day 45 (midpoint), and Day 90 (post-intervention) | — |
Secondary
| Measure | Time frame |
|---|---|
| Muscle Mass: Appendicular skeletal muscle mass (ASM) measured via bioelectrical impedance analysis (BIA)Timepoint: Day 0 (baseline), Day 45 (midpoint), and Day 90 (post-intervention);Muscle Strength: Maximum grip strength measured using a calibrated hand dynamometer.Timepoint: Day 0 (baseline), Day 45 (midpoint), and Day 90 (post-intervention);Muscle Stem cell activation: Concentration of PAX7 & MYF5 protein (ng/mL) in serum, measured via ELISATimepoint: Day 0 (baseline) and Day 90 (post-intervention);Cognitive Assessment: MoCA questionnaire: Montreal Cognitive assessment questionnaire based assessment of cognitionTimepoint: Day 0 (baseline), Day 45 (midpoint), and Day 90 (post-intervention;Quality of Life: Questionnaire based assessment of quality of life, using Sarcopenia related quality of life (SarQoL) questionnaireTimepoint: Day 0 (baseline), Day 45 (midpoint), and Day 90 (post-intervention) | — |
Countries
India
Contacts
Public ContactDr Monika Pathania
AIIMS Rishikesh
Outcome results
None listed