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Studying the Connection Between Macular Nerve Thickness and Vision Test Patterns in Glaucoma Suspects

Correlation of Macular Ganglion Cell Complex (GCC) Thickness on Optical Coherence Tomography (OCT) With 24-2C SITA Faster and 10-2 SITA Standard on Humphrey Visual Fields in Glaucoma Suspects A Cross-Sectional Observational Study. - Nil

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2025/07/092047
Enrollment
92
Registered
2025-07-30
Start date
Unknown
Completion date
Unknown
Last updated
2025-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: H400- Glaucoma suspect

Interventions

Intervention1: Nil: Nil Intervention2: Nil: Nil

Sponsors

Centre For Sight Eye Hospital
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Age greater than or equal to 18 years to 60 years Best-corrected visual acuity (BCVA) greater than or equal to 6/12 Ocular Hypertension Risk factors for glaucoma suspicion: Ethnicity: African, Hispanic, or Asian Family history of glaucoma Elevated IOP greater than or equal to 21 mmHg Thin central corneas (less than 530-550 m thickness) High Myopia Long term steroid medications Comorbidities like DM, HTN and Cardiovascular Diseases Open Angles on Gonioscopy 24-2C SITA Faster and 10-2 SITA Standard Humphrey Visual Field tests with: Reliable fields (Fixation losses less than 20 percent, False positives and False negatives less than 15 percent) Optic nerve head changes suspicious of glaucoma: Increased cup-disc ratio greater than or equal to 0.6:1 Asymmetrical discs greater than or equal to 0.2 Neuro Retinal Rim notching and/or thinning Nasalization of retinal vessels Disc hemorrhages Retinal Nerve Fiber Layer Wedge defects

Exclusion criteria

Exclusion criteria: Established Glaucoma cases (early, moderate, advanced, POAG, Normal Tension Glaucoma, Secondary glaucoma due to Pseudo-exfoliation Syndrome or Pigment Dispersion Syndrome, etc.) Non-glaucomatous optic neuropathies Co- existing Vitreo-Retinal pathologies: Retinal dystrophies, degeneration and detachments Diabetic retinopathy with macular changes Age-related macular degeneration Epiretinal membrane Associated CRVO, BRVO, CRAO and BRAO Unreliable visual field tests (fixation losses greater than 20 percent, false positives and false negatives greater than 15 percent) Media Opacities affecting OCT or HVF test results: Corneal opacity Significant cataract (greater than or equal to NS3) Vitreous hemorrhage Dense posterior capsular opacification Intraocular inflammation: anterior or posterior uveitis

Design outcomes

Primary

MeasureTime frame
To study the correlation between Macular GCC thickness measured by OCT and visual field sensitivity at the additional central test points in the 24-2C SITA Faster and 10-2 SITA Standard HVF in glaucoma suspects.Timepoint: Baseline—

Secondary

MeasureTime frame
1.To assess the sensitivity and efficacy of GCC analysis by quantifying macular GCC thickness using OCT in glaucoma suspects. 2.To assess the visual field sensitivity at additional central 10degree test points using the 24-2C SITA Faster and 10-2 SITA Standard HVF in glaucoma suspects. 3.To study and determine the utility of Macular GCC analysis and central 10degree cluster points on 24-2C SITA Faster and 10-2 SITA Standard by analyzing the statistical correlation between them in glaucoma suspects.Timepoint: Baseline—

Countries

India

Contacts

Public ContactDr Kiran Kirtani

Centre For Sight Eye Hospital

drkiranp2k@gmail.com9953775085

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026