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Pulmonary hypertension phenotypes in neonates - A prospective cohort study

Evaluation of a physiologic phenotype-based algorithm in diagnosis and classification of pulmonary hypertension in neonates A prospective cohort study - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2025/07/092022
Enrollment
200
Registered
2025-07-30
Start date
Unknown
Completion date
Unknown
Last updated
2025-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: P288- Other specified respiratory conditions of newborn

Interventions

Intervention1: Nil: Nil

Sponsors

JIPMER
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Inclusion criteria: Neonates admitted to NICU with a diagnosis of echo-proven PH.

Exclusion criteria

Exclusion criteria: Exclusion criteria: Neonates with structural heart disease other than patent ductus arteriosus (PDA). Major congenital malformations. Neonates who die within 24 hours of life.

Design outcomes

Primary

MeasureTime frame
To estimate the proportion of different identifiable PH phenotypes (flow driven, resistance driven, post- capillary, or mixed) in neonates with pulmonary hypertensionTimepoint: Primary outcome can occur at any point of time until death or discharge from hospital. The time point might be anywhere between Day 1 of life to day 28 of life, based on when the outcome occurs

Secondary

MeasureTime frame
1. To analyze the factors associated with mortality in PH 2. To analyze the differences in phenotype and echo parameters between term & preterm infants with PH 3. To estimate the survival to discharge rates in neonates with PHTimepoint: The above mentioned secondary outcomes can occur at any point of time until death or discharge from hospital. The time point might be anywhere between Day 1 of life to day 28 of life, based on when the outcome occurs

Countries

India

Contacts

Public ContactMurugesan A

JIPMER

murugesan89@gmail.com9442455767

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026