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Nuclear factor erythroid 2-related factor 2 (Nrf2) and Signal transducer and activator of transcription 3 (STAT3) levels in patients with periodontal disease and diabetes.

Estimation of Nuclear factor erythroid 2-related factor 2 (Nrf2) and Signal transducer and activator of transcription 3 (STAT3) levels in saliva and serum in generalized periodontitis patients with and without Type 2 Diabetes mellitus (T2DM). - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2025/07/091960
Enrollment
80
Registered
2025-07-29
Start date
Unknown
Completion date
Unknown
Last updated
2025-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: E119- Type 2 diabetes mellitus without complications

Interventions

Intervention1: Nil: Nil Intervention2: NIL: NIL

Sponsors

Dr Chatragadda Swathi
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.Patients who have not received any periodontal treatment in previous six months. 2. Patients diagnosed with T2DM as per American Diabetes Association criteria (2019). 3.Patients with a diagnosis of generalized periodontitis as per World Workshop Classification criteria (2017).

Exclusion criteria

Exclusion criteria: 1.Smokers and alcoholics. 2.Patients with systemic diseases like hypertension, cardiovascular diseases, rheumatoid arthritis, tumors, autoimmune diseases and renal diseases. 3.Pregnant and lactating females. 4.Any other systemic disease which can alter the course of periodontal disease. 5.Patients on medications like anti-inflammatory drugs, antibiotics and anti-epileptic drugs in the past 6 months. 6.Postmenopausal women.

Design outcomes

Primary

MeasureTime frame
To evaluate salivary and serum levels of Nuclear factor erythroid 2-related factor 2 (Nrf2) and Signal transducer and activator of transcription 3 (STAT3) in periodontitis and T2DM patients at baselineTimepoint: Baseline—

Secondary

MeasureTime frame
To explore correlation of Nuclear factor erythroid 2-related factor 2 (Nrf2) & Signal transducer & activator of transcription 3 (STAT3) & clinical, biochemical & demographic parameters at baselineTimepoint: Baseline—

Countries

India

Contacts

Public ContactDr Ashish S Nichani

The Oxford Dental college

nichaniashish@hotmail.com9845252203

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026