Health Condition 1: I10- Essential (primary) hypertension
Conditions
Interventions
Intervention1: Oseltamivir: per oral 75mg once a day for 12 weeks
Control Intervention1: placebo: per oral once daily for 12 weeks
Sponsors
Postgraduate Institute of Medical Education and Research
Eligibility
Inclusion criteria
Inclusion criteria: 18year of age or older, regardless of gender. Diagnosed with essential hypertension for at least 1 year Have been on stable antihypertensive medication for a minimum of 3 months before screening. Have a diagnosis of LVH confirmed by echocardiography, with LVMI of more than or equal to 115g/m for males and more than equal to 95g/m for females. Provide written informed consent
Exclusion criteria
Exclusion criteria: Women who are pregnant and lactating Patients with valvular heart diseases (MR, AR). Patient with inadequate echocardiographic windows. Suboptimal automated speckle tracking across multiple myocardial segment. Any LV regional wall motion abnormalities. Atrial fibrillation, frequent ectopic, left bundle branch block, paced rhythm, or atrioventricular block. Known secondary causes of HTN. Known chronic kidney disease, retinopathy, or cerebrovascular diseases. Known case of congenital heart disease. Any history of previous cardiac surgery
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in LVGLSTimepoint: At 0, 12, and 24 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in left ventricular mass index.Timepoint: 12, and 24 weeks;Changes in fractional shorteningTimepoint: 12 and 24 weeks;Left ventricle posterior wall diameter in systole (LVPWs)Timepoint: 12 and 24 weeks;Left ventricle posterior wall diameter in diastole (LVPWd)Timepoint: 12 and 24 weeks;Interventricular septal thickness systole (IVSTs)Timepoint: 12 and 24 weeks;Interventricular septal thickness diastole (IVSTd)Timepoint: 12 and 24 weeks;incidence of adverse events and serious adverse eventsTimepoint: 12 and 24 weeks | — |
Countries
India
Contacts
Public ContactDr Ashish Kakkar
Postgraduate Institute of Medical Education and Research
Outcome results
None listed