Motor imagery based EEG study for rehabilitation of stroke patients.

Closed Loop Motor Imagery Brain-Computer Interface using Sensorimotor Rhythms and Error-Related Potentials for Neurorehabilitation of Stroke Patients

Status

Active, not recruiting

Phases

Phase 3Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/07/091936

Enrollment

Registered

2025-07-29

Start date

Unknown

Completion date

Unknown

Last updated

2025-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: G00-G99- Diseases of the nervous system Health Condition 2: G468- Other vascular syndromes of brainin cerebrovascular diseases

Interventions

Intervention1: BCI- based intervention: EEG based BCI intervention will be done using MI & ErrP paradigms. Patients will undergo 3 sessions at 1 weekly interval and there will be 100 trials each lasti

Eligibility

Inclusion criteria

Inclusion criteria: l. Stroke patients with Motor paresis or plegia, assessed by Medical Research Council (MRC) grades 2. Both Hemorrhagic strokes and ischemic stroke (TOAST criteria) will be included 3.Cerebral venous thrombosis with focal deficits 4.First ever ischemic/hemorrhagic stroke 5.Patients will be recruited in both acute stages and chronic stages after the onset of stroke 6.CTIMRTshows evidence of stroke(infarct/hemorrhage) 7.Moderate to severe impairment of upper extremity function assessed by FMMA (Fugel-Meyer et al., 1975) score 10--50 8.Able to understand simple commands and imagine hand movements 9.Patients with adequate motivation and cognitive functioning to perform the experiments/games (MMSE score ranging from 15 to 30 preferably more than 24)

Exclusion criteria

Exclusion criteria: l.Unconscious and Modified Rankin scale score 4 2.Those requiring ventilator support 3.Serious cardiovascular illness 4.Severe Respiratory Distress/ renal diseases 5.Patients with Psychiatric illness 6.Non cooperative participants 7.Stroke Mimics 8.Patients with Isolated CNS vasculitis/ systemic vasculitis, aneurysmal SAH 9.Transient ischemic events

Design outcomes

Primary

Measure	Time frame
The Fugl Meyer scale for upper limb, Modified Rankin scale (MRC)Timepoint: At baseline and after every session weekly for 3 weeks of BCI intervention	—

Secondary

Measure	Time frame
(i) Classification accuracy, Subjectivity & Specificity, (ii) Spatial brain activation maps (iii) Resting-state functional network connectivity (an indicator of the overall performance of the brain) & DTI metrics (iv) Statistical analysis (Wilcoxon non-parametrical t-tests) to assess the statistical significance of the enhancements made during each session (v) training completion, adherence rates & adverse events (vi) User evaluation of the experiment and tasks.Timepoint: Baseline & at the end of every session weekly for 3 weeks of BCI intervention	—

Measure

Time frame

(i) Classification accuracy, Subjectivity & Specificity, (ii) Spatial brain activation maps (iii) Resting-state functional network connectivity (an indicator of the overall performance of the brain) & DTI metrics (iv) Statistical analysis (Wilcoxon non-parametrical t-tests) to assess the statistical significance of the enhancements made during each session (v) training completion, adherence rates & adverse events (vi) User evaluation of the experiment and tasks.Timepoint: Baseline & at the end of every session weekly for 3 weeks of BCI intervention

—

Countries

India

Contacts

Public ContactSubasree R

NIMHANS

subasree.ramakrishnan@gmail.com7899214328

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026