Health Condition 1: 3- Administration Health Condition 2: G540- Brachial plexus disorders
Conditions
Interventions
Intervention1: Dexamethasone as adjuvants with Bupivacaine and Lignocaine with Adrenaline: 10 ml of 2% Lignocaine + 10 ml of 0.5% Bupivacaine + 0.1 ml Adrenaline 1:1000 + 4 mg Dexamethasone
Control In
Sponsors
Dr KOUSIKA K
Eligibility
Inclusion criteria
Inclusion criteria: 1. Adult patients aged 18 to 65 years undergoing elective upper limb surgeries under Ultrasound guided supraclavicular brachial plexus block. 2. Patients classified as American Society of Anesthesiologists physical status I or II. 3. Patients willing to undergo Ultrasound-guided supraclavicular brachial plexus block. 4. Patients who provide written informed consent for participation in the study. 5. Patients with normal coagulation profile PT,APTT ,no bleeding diasthesis, platelet count more than 1 lakh and no contraindication to regional anesthesia.
Exclusion criteria
Exclusion criteria: 1. Patients with known allergy or hypersensitivity to local anesthetics,Adrenaline, Dexamethasone, or Dexmedetomidine. 2. Patients with coagulopathy or on anticoagulant therapy. 3. Patients with infection at the site of block or local skin infections Abscess, Hematoma, Folliculitis, Impetigo etc 4. Patients with pre-existing neurological deficits in the upper limb to be operated. 5. Patients with cardiopulmonary disease e.g., uncontrolled hypertension, ischemic heart disease, heart failure, COPD. 6. Pregnant or lactating women. 7. BMI more than 40 kg per m morbid obesity making ultrasound-guided block difficult.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1.To compare the onset time of sensory and motor blockade. 2.To compare the duration of sensory and motor blockade. 3.To evaluate the incidence and type of adverse drug reactions associated with each adjuvant. Timepoint: 0 hour 15min 30min 45min 60min 90min 120min 3hour 4 hour 5 hour 6 hour 7 hour 8 hour 9 hour 10 hour 11 hour TILL VAS MORE THAN OR EQUALTO 4 | — |
Secondary
| Measure | Time frame |
|---|---|
| 1.To compare the pharmacological interactions between local anesthetics and Dexmedetomidine and Dexamethasone in producing neuronal blockade. 2.To assess the hemodynamic effects as indicators of systemic pharmacological effects of Dexamethasone and Dexmedetomidine Timepoint: 0 hour 15min 30min 45min 60min 90min 120min 3hour 4 hour 5 hour 6 hour 7 hour 8 hour 9 hour 10 hour 11 hour TILL VAS SCORE MORE THAN 4 | — |
Countries
India
Contacts
Public ContactDr KOUSIKA K
Professor & HOD, Department of Pharmacology, SABVMCRI, Bengaluru, Karnataka, India
Outcome results
None listed