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A Study on How the Timing Between Fentanyl and Thiopentone Affects Anaesthesia Dose Requirements in Adults

Comparison of different time intervals between fentanyl and thiopentone on entropy guided induction dose of thiopentone in adult patients under general anaesthesia - nil

Status
Active, not recruiting
Phases
Phase 2Phase 3
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/07/091893
Enrollment
132
Registered
2025-07-28
Start date
Unknown
Completion date
Unknown
Last updated
2025-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: Z018- Encounter for other specified special examinations

Interventions

Intervention1: Fentanyl 2 g/kg followed by thiopentone after 3 minutes: In Group B, patients will receive intravenous fentanyl 2 g/kg as a bolus. After a time interval of 3 minutes, intravenous thio

Sponsors

Dr Anjali yadav
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: ASA grade: American society of Anaesthesiologists physical status grade I- II scheduled for elective surgery under general anaesthesia.

Exclusion criteria

Exclusion criteria: 1.Known allergic reactions to sulpha group drugs. 2.Patients on drugs which are likely to interfere with induction agent or hemodynamic parameters. 3.Neurology or neurosurgery patients. 4.Patients posted for emergency surgery.

Design outcomes

Primary

MeasureTime frame
Total dose of thiopentone required for induction of anaesthesia in the groups.Timepoint: 0- 10 minutes after thiopentone administration.

Secondary

MeasureTime frame
1.The incidence of abnormal movement after the initial dose of thiopentone. 2.The incidence of heart rate, oxygen saturation, and blood pressure variations in these patients.Timepoint: 1.0-10 minutes after thiopentone administration. 2.Every 2 minutes from 0 to 10 minutes after thiopentone administration and thereafter every 5 minutes from 10 to 30 minutes post-induction.

Countries

India

Contacts

Public ContactDr. Sandeep Kumar

Abvims and Dr. rml hospital

drsandeeprml@gmail.com9868910835

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026