None listed
Conditions
Interventions
Intervention1: Nil: Nil
Intervention2: Inhaled Dexmedetomidine (1 mcg/kg): 32 subjects will be administered. Dexmedetomidine nebulization at 1 mcg dose diluted in saline to make a total of 5 ml Group
Sponsors
SRMS IMS
Eligibility
Inclusion criteria
Inclusion criteria: Patients aged 18-60 years of either sex ASA physical status I/II
Exclusion criteria
Exclusion criteria: ASA Grade 3 and 4 Unwillingness to be a part of the trial or patient refusal Allergy to the study drugs Uncontrolled comorbidities [Diabetes mellitus, Hypertension, obese, neurovascular surgeries] and systemic illnesses involving cardiovascular, nervous or respiratory system, any renal or liver disease Hemodynamically unstable patient Pregnancy Anticipated difficult airway / more than 1 attempt / more than 15 seconds for intubation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To evaluate the efficacy of nebulized dexmedetomidine [1 mcg / kg] on hemodynamic responses and on stress response to laryngoscopy and intubation. To evaluate the efficacy of nebulized dexmedetomidine [2 mcg / kg] on hemodynamic and on stress response to laryngoscopy and intubation.Timepoint: Hemodynamic parameters HR, SBP, DBP, MAP will be recorded at baseline than after 5 min and 10 min after inhaling nebulization and at immediately post induction, and subsequently at 1 min interval for 1st 10 minutes following laryngoscopy and intubation. | — |
Secondary
| Measure | Time frame |
|---|---|
| To compare the effect of nebulized dexmedetomidine [1 mcg / kg vs 2 mcg / kg] on hemodynamics and myocardial oxygen demand. To observe adverse effects/ events if any.Timepoint: Hemodynamic parameters HR, SBP, DBP, MAP will be recorded at baseline than after 5 min and 10 min after inhaling nebulization and at immediately post induction, and subsequently at 1 min interval for 1st 10 minutes following laryngoscopy and intubation. | — |
Countries
India
Contacts
Public ContactDr Vishwadeep Singh
Department of Anaesthesia , Shri Ram Murti Smarak Institute of Medical Sciences (SRMS IMS)
Outcome results
None listed