Effectiveness of bone graft and fibrin treatment compared to standard healing in adults after tooth extraction

Efectiveness of xenograf and injectable PRF (I-PRF) Compared to Xenograft, and unassisted healing for Socket Preservatlon in Adults U ndergoing Tooth Extraction - Nil

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/07/091854

Enrollment

Registered

2025-07-28

Start date

Unknown

Completion date

Unknown

Last updated

2025-11-17

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: I-PRF ,Xenograft and membrane: Socket preservation technique using injectable platelet rich fibrin,xenograft and membrane Duration 6 month Control Intervention1: Group 2 Xenograft and

Eligibility

Inclusion criteria

Inclusion criteria: 1. Maxillary and mandibular single rooted teeth requiring extraction . 2. Type 1,Type 2 extraction socket (Endodontic origin, fracture, severe caries, Periodontal origin, periodontal-endodontic combined ) 3. more than or equal to 18 years of age 4. Patients with no systemic diseases

Exclusion criteria

Exclusion criteria: 1. Uncontrolled diabetes 2. Smokers (more than or equal to10 cigarettes/day) 3. Use of immunosuppressing medication 4. Use of anticoagulants 5. Pregnant women 6. Patients with Stage III or IV periodontal disease Grade C

Design outcomes

Primary

Measure	Time frame
Clinically horizontal ridge width(buccolingual and mesiodistal) and vertical (mid-buccal, mid-lingual, mesial, and distal) ridge height.2 Using CBCT , (1) the mean width difference between the outer borders of the buccal and lingual cortical plates at 1, 3, and 5 mm socket depths, (2) the mean width of the buccal plate at the same depths.3.Histomorphometric analysis of the percentage of vital boneTimepoint: Clinical and radiographic meaurements at baseline and at 6 months Histomorphometric analysis at 6months	—

Measure

Time frame

Clinically horizontal ridge width(buccolingual and mesiodistal) and vertical (mid-buccal, mid-lingual, mesial, and distal) ridge height.2 Using CBCT , (1) the mean width difference between the outer borders of the buccal and lingual cortical plates at 1, 3, and 5 mm socket depths, (2) the mean width of the buccal plate at the same depths.3.Histomorphometric analysis of the percentage of vital boneTimepoint: Clinical and radiographic meaurements at baseline and at 6 months Histomorphometric analysis at 6months

—

Secondary

Measure	Time frame
Healing Index socket length bone density Timepoint: 3rd 7th 14th 21 days baseline & after 6 months baseline & after 6 months	—

Countries

India

Contacts

Public ContactPRAMEETHA GEORGE ITTYCHERIA

Pushpagiri college of dental sciences

prameethageorgeittycheria@gmail.com9495080021

Outcome results