Health Condition 1: C969- Malignant neoplasm of lymphoid, hematopoietic and related tissue, unspecified
Conditions
Interventions
Intervention1: Nil: Nil
Intervention2: Nil: Nil
Sponsors
ALL INDIA INSTITUTE OF MEDICAL SCIENCES
Eligibility
Inclusion criteria
Inclusion criteria: 1. Patient willing to participate in the study and to provide written informed consent 2. Patients aged 12yrs to 65 yrs. undergoing Conditioning for autologous or allogenic hematopoietic stem cell transplant 3. Weight more than or equal to 30 kg
Exclusion criteria
Exclusion criteria: 1) Hepatic dysfunction (aminotransferase/alanine aminotransferase more than 3 times of upper normal limit, serum bilirubin more than 2 times of upper normal limit) 2) Patients with cardiac arrhythmia, uncontrolled congestive heart failure, or acute myocardial infarction within the previous 6 months 3) Preexisting psychiatric disorders 4) Severe renal impairment (GFR less than 50 ml/hr. or creatinine more than 1.5 times upper normal limit) 5) Pregnant or lactating women 6) Refusal to participate in the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To find the association between baseline microbiome and chemotherapy induced nausea vomiting in patients undergoing hematopoietic stem cell transplantTimepoint: Baseline and at the end of 6 days from last day of conditioning regimen | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. To assess the association between the gut microbiome composition and the metabolomics profile with CINV 2. To evaluate the association between dietary intake and gut microbiome composition with CINV 3. To perform an integrative analysis to explore: The interaction between microbiome, metabolomics, diet and their combined effect on CINV. Timepoint: Baseline | — |
Countries
India
Contacts
Public ContactDr. Deepam Pushpam
ALL INDIA INSTITUTE OF MEDICAL SCIENCES
Outcome results
None listed