A comparative study between Diltiazem and Esmolol in reducing the rise in heart rate and blood pressure that often happens when the breathing tube is removed after surgery (a process called extubation).

A Comparative study between Diltiazem and Esmolol in attenuating the cardiovascular responses to endotracheal extubation in patients undergoing laparoscopic cholecystectomy under general anesthesia in a tertiary care hospital in Sikkim. A double blinded randomized controlled study. - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/07/091824

Enrollment

Registered

2025-07-28

Start date

Unknown

Completion date

Unknown

Last updated

2025-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K801- Calculus of gallbladder with othercholecystitis Health Condition 2: K80- Cholelithiasis

Interventions

Intervention1: A Randomized control parallel group trial. A comparative study between Diltiazem and Esmolol in attenuating the cardiovascular response to endotracheal extubation: Two minutes after adm

Eligibility

Inclusion criteria

Inclusion criteria: ASA 1 & ASA 2 Patient undergoing elective surgery under general anaesthesia

Exclusion criteria

Exclusion criteria: ASA 3 & ASA 4 Patient refusal Pregnant female

Design outcomes

Primary

Measure	Time frame
Diltiazem would be more effective than Esmolol in attenuating blood pressure changes and Esmolol would be more effective than Diltiazem in attenuating heart rate changesTimepoint: At the time of giving study drug. Then every 2 minutes till the patient gets extubated. Post extubation, Every 3 minutes for the next 15 minutes.	—

Secondary

Measure	Time frame
To observe for incidence of adverse effects (bradycardia, arrythmia, hypotension)Timepoint: At the time of giving study drug. Then every 2 minutes till the patient gets extubated. Post extubation, every 3 minutes for the next 15 minutes.	—

Countries

India

Contacts

Public ContactDr Silash Rai

Sikkim Manipal Institute of Medical science

Meyong.b@smims.edu.in9614389839

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026