Health Condition 1: 4- Measurement and Monitoring
Conditions
Interventions
Intervention1: Dexmedetomidine: Group A (Intervention group) will receive sevoflurane and Dexmedetomidine (Loading = 1 /kg & 0.5 /kg /hr infusion for maintenance)
Control Intervention1: Saline: Group
Sponsors
AIIMS NEW DELHI
Eligibility
Inclusion criteria
Inclusion criteria: Patients aged between 18 and 60 of either gender belonging to ASA physical status I II undergoing emergency decompressive craniotomy for traumatic brain injury requiring general anesthesia
Exclusion criteria
Exclusion criteria: Patients with mild-moderate head injury GCS more than 8 Patients with SBP less than 90 mmHg Previous history of heart disease or surgery. Hemodynamic instability requiring medical or mechanical attention, Severe hepatic and renal insufficiency, and Severe chronic obstructive pulmonary disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Syndecan-1 and Heparan sulfate (HS) levels with dexmedetomidine-based anesthesia in TBI patients at various time pointsTimepoint: baseline T0 preoperative period just before induction of anesthesia T1 at the end of the surgery T2-6 hr after surgery T3-24 hr postoperatively | — |
Secondary
| Measure | Time frame |
|---|---|
| Duration of mechanical ventilation and hospital length of stay (d), and neurological outcomes at 30- and 90-day post-discharge will be assessed using the extended Glasgow Coma Scale (GOSE). Outcome will be dichotomized into favourable (GOSE 5 to 8) and unfavorable (GOSE 1 to 4) outcomesTimepoint: Preoperative period just before induction of anesthesia baseline (T0), at the end of the surgery i.e. skin closure (T1), 6 hr after surgery (T2) and 24 hr postoperatively (T3). | — |
Countries
India
Contacts
Public ContactDr Niraj Kumar
All India Institute of Medical Sciences, New Delhi
Outcome results
None listed