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A study comparing two eye drops, cyclosporine and lifitegrast, for patients with dry eye disease

Comparative study on efficacy between topical 0.05% Cyclosporine and topical 5% Lifitegrast in dry eye disease - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/07/091757
Enrollment
42
Registered
2025-07-25
Start date
Unknown
Completion date
Unknown
Last updated
2025-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: H041- Other disorders of lacrimal gland

Interventions

Intervention1: Topical medications, Cyclosporine and Lifitegrast eye drops will be advised to dry eye patients.: Two group of patients in our study. One group will receive Cyclosporine eye drops and t

Sponsors

Sankara Eye Hospital, Shivamogga
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1 Patients who are diagnosed to have Moderate or Severe Dry eye disease 2 Who are compliant to medication 3 Willing to give consent for study

Exclusion criteria

Exclusion criteria: 1 H/o using steroid eye drops in past one month 2 Presence of other ocular co morbidities - glaucoma, lid abnormalities 3 Presence of MGD 4 H/o ocular trauma or infection in past 3 months 5 Corneal disorders affecting sensitivity 6 H/o Contact lens usage in past 3 months 7 Pregnant and lactating mothers 8 H/o intraocular surgery, refractive surgery in past 3 months 9 Presence of allergic conjunctivitis 10 H/o viral keratitis 11 Presence of pterygium 12 H/o punctal plug usage in last 3 months 13 H/o Steven-Jonson Syndrome, Ocular Pemphigoid 14 H/o usage of topical cyclosporine in past 3 months

Design outcomes

Primary

MeasureTime frame
To compare the objective parameters which includes Schirmer tear test, Tear Break Up Time, Corneal and Conjunctival fluorescein staining, in patients treated with 0.05 percent Cyclosporine versus 5 percent Lifitegrast in dry eye diseaseTimepoint: At presentation, Day 15 and Day 45

Secondary

MeasureTime frame
To compare the subjective response (OSDI) in patients treated with 0.05% Cyclosporine versus 5% Lifitegrast in Dry eye diseaseTimepoint: At presentation, Day 15 and Day 45

Countries

India

Contacts

Public ContactDr Lakshitha N

Sankara Eye Hospital, Shivamogga

dr.roopasree@gmail.com8884920286

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026