None listed
Conditions
Interventions
Intervention1: Oxymetazoline 0.05% (Spray A): Oxymetazoline 0.05% Nasal spray-one puff per nostril is administered
Intervention2: Xylometazoline 0.1% (Spray B): Xylometazoline 0.1% Nasal spray-one puf
Sponsors
Dr Charumathi P C
Eligibility
Inclusion criteria
Inclusion criteria: 1. Healthy human volunteers aged 18 35 years 2. Normosmic (normal sense of smell)
Exclusion criteria
Exclusion criteria: 1. Nasal disorders, allergies, chronic rhinitis, current smokers 2. Upper respiratory tract infection in the past 4 weeks 3. Neurological or psychiatric disorders 4. Cardiovascular disease or hypertension 5. Current use of decongestants or antihistamines
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in odor identification scores across sprays and timepoints (olfactory test) and Changes in Stroop interference score and memory recall (5 word memory recall test and stroop test)Timepoint: 0 minute(baseline), +5 minutes. +10 minutes, +30 minutes and +60 minutes followed by 48 hours washout period for each drug | — |
Secondary
| Measure | Time frame |
|---|---|
| Change in nasal patency (Visual Analogue Scale) and Comparison of onset and duration of effectsTimepoint: followed by 48 hours washout period for each drug | — |
Countries
India
Contacts
Public ContactDr Charumathi P C
KEMPEGOWDA INSTITUTE OF MEDICAL SCIENCES
Outcome results
None listed