Health Condition 1: G01- Meningitis in bacterial diseases classified elsewhere
Conditions
Interventions
Intervention1: Extended Prednisolone therapy: Extended group will receive weight based prednisolone for 2 months then tapered off in 3 rd month.Prednisolone will be taperedby 10mg every week and 5mg i
Sponsors
Professor Jayantee Kalita
Eligibility
Inclusion criteria
Inclusion criteria: 1.Patients with diagnosed TBM on the following criteria. Presence of essential and 3 of 4 supportive criteria will be considered highly probable and 2 supportive criteria as probable TBM. Presence of AFB in CSF smear or culture, positive PCR for M. tuberculosis in CSF will be considered definitive evidence of TBM 2-Age 15years to 70 years 3-Gender-Both male and female
Exclusion criteria
Exclusion criteria: The patients with malaria, septic, fungal and carcinomatous meningitis, HIV, resistant TB, head injury, stroke, tumors, malignancy, chronic renal failure, hepatic failure, heart failure, chronic obstructive pulmonary disease, asthma children less than 15 years and elderly more than 70 years ,pregnancy, lactation, and those having life expectancy less than 6month due to other disease will be excluded. The antitubercular drug induced hepatitis however will be included.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Paradoxical reaction at 6weeks and 3months between standard and extended corticosteroid groupTimepoint: Paradoxical reaction at 6weeks and 3months between standard and extended corticosteroid group | — |
Secondary
| Measure | Time frame |
|---|---|
| 1.Death within 3month 2.Functional outcome at 3 and 6 months using modified Rankin Scale (mRS). 3.Occurrence of drug induced hepatitis 4. Occurrence of CSW 5. Occurrence of visual loss 6. Corticosteroid related side effects: hypertension, weight gain, hyperglycemia, infection, fracture. Timepoint: 6 weeks and 3months and 6 months | — |
Countries
India
Contacts
Public ContactProfessor Jayantee Kalita
Sanjay gandhi post graduate institute of medical sciences
Outcome results
None listed