A clinical study of laser photobiomodulation synergy with lignocaine and tramadol to increase depth of anesthesia

Laser photobiomodulation synergy with lignocaine and tramadol An In vivo study - NIL

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/07/091525

Enrollment

Registered

2025-07-23

Start date

Unknown

Completion date

Unknown

Last updated

2025-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K029- Dental caries, unspecified

Interventions

Intervention1: evaluate depth of anesthesia during the root canal treatment procedure only.(2 hours): with tramadol and lignocaine during the root canal treatment procedure only (2 hours) Control Inte

Eligibility

Inclusion criteria

Inclusion criteria: Vital Maxillary Molar requiring Root Canal Treatment. Vitality Test : Positive or prolonged response (Using Cold test & Electric pulp test)

Exclusion criteria

Exclusion criteria: Non-Vital teeth. All other maxillary teeth. Mandibular teeth. Teeth with periapical lesion. Patients allergic to lignocaine (local anesthetics). Pregnant & lactating women. Patients having habit of alcohol. Those who have systemic diseases, immunocompromised conditions, psychiatric condition

Design outcomes

Primary

Measure	Time frame
Photobiomodulation increases depth of anesthesia during access cavity preparation.Timepoint: Visual analogue scale(VAS) for pain perception recorded during dentin cutting (VAS 1) and at entry into the pulp (VAS 2). The patient s response will be noted based on VAS score during dentin cutting, and during pulp dropping(assessment while ongoing root canal treatment within 2hours of anesthesia delivery)	—

Measure

Time frame

Photobiomodulation increases depth of anesthesia during access cavity preparation.Timepoint: Visual analogue scale(VAS) for pain perception recorded during dentin cutting (VAS 1) and at entry into the pulp (VAS 2). The patient s response will be noted based on VAS score during dentin cutting, and during pulp dropping(assessment while ongoing root canal treatment within 2hours of anesthesia delivery)

—

Secondary

Measure	Time frame
Chances of achievement of Pulpal anesthesia increases when tramadol hydrochloride & lignocaine hydrochloride both are administered.Timepoint: Visual analogue scale(VAS) for pain perception recorded during dentin cutting (VAS 1) & at entry into the pulp (VAS 2). The patient s response will be noted based on VAS score during dentin cutting, & during pulp dropping while ongoing root canal treatment only.( within 2 hours of anaesthesia delivery)	—

Measure

Time frame

Chances of achievement of Pulpal anesthesia increases when tramadol hydrochloride & lignocaine hydrochloride both are administered.Timepoint: Visual analogue scale(VAS) for pain perception recorded during dentin cutting (VAS 1) & at entry into the pulp (VAS 2). The patient s response will be noted based on VAS score during dentin cutting, & during pulp dropping while ongoing root canal treatment only.( within 2 hours of anaesthesia delivery)

—

Countries

India

Contacts

Public ContactDr Kailash Attur

Narsinhbhai Patel Dental college and hospital

atturkailash@gmail.com9727752499

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026