Health Condition 1: C220- Liver cell carcinoma
Conditions
Interventions
Intervention1: Nil: Nil
Sponsors
Department of Radiotherapy and Clinical Oncology, PGIMER, Chandigarh
Eligibility
Inclusion criteria
Inclusion criteria: 1. Diagnosis of Hepatocellular Carcinoma (HCC) with radiologically or histologically confirmed portal vein tumor thrombosis (PVTT). 2. ECOG Performance Status of 0 2 3. BCLC stage C 4. Child-Pugh Class A or B liver function status 5. Adequate remaining liver volume, defined as at least 700 cc of uninvolved liver tissue.
Exclusion criteria
Exclusion criteria: 1. Presence of metastatic disease outside the liver. 2. Previous radiotherapy to the liver. 3. Child-Pugh Class C liver function status with Child pugh score of 10 to 15.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| 1.To evaluate the radiological response of portal vein tumor thrombus (PVTT) following SBRT using mRECIST criteria, assessing changes in tumor viability based on arterial-phase enhancement and measuring PVTT size pre- and post-SBRT at 2, 4, and 6 months. 2.We will also measure the biochemical level of AFP and PIVKAA II before SBRT and after SBRT at 2 months ,4 months and 6 months. Timepoint: 1.To evaluate the radiological response of portal vein tumor thrombus (PVTT) following SBRT using mRECIST criteria, assessing changes in tumor viability based on arterial-phase enhancement and measuring PVTT size pre- and post-SBRT at 2, 4, and 6 months. 2.We will also measure the biochemical level of AFP and PIVKAA II before SBRT and after SBRT at 2 months ,4 months and 6 months. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. To assess acute toxicity profile of SBRT in patients with PVTT, using RTOG scoring criteria.Timepoint: at third fraction 1month 2month | — |
Countries
India
Contacts
Public ContactDr Rakesh Kapoor
Postgraduate Institute of Medical Education and Research (PGIMER), Chandigarh
Outcome results
None listed