A study in adults to compare three treatments for rebuilding the lost gum between teeth using injectable platelet rich fibrin autologous fibrin glue and hyaluronic acid gel

Comparative evaluation of Injectable Platelet Rich Fibrin, Autologous Fibrin Glue and Hyaluronic Acid Gel for papilla reconstruction; A randomised clinical trial - nill

Status

Active, not recruiting

Phases

Phase 3Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/07/091422

Enrollment

Registered

2025-07-22

Start date

Unknown

Completion date

Unknown

Last updated

2025-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K088- Other specified disorders of teethand supporting structures

Interventions

Intervention1: I.: Injectable Platelet Rich Fibrin (i-PRF) II. Autologous Fibrin Glue (AFG) III. Hyaluronic Acid (HA) Gel: I.i-PRF prepared from autologous blood using low-speed centrifugation will be

Eligibility

Inclusion criteria

Inclusion criteria: 1.Patients aged between 18 to 55 years 2.Presence of interdental papillary loss in the maxillary anterior region 3.Good general health with no systemic conditions affecting periodontal healing 4.Willingness to participate and provide written informed consent 5.Presence of plaque index and gingival index scores within acceptable range

Exclusion criteria

Exclusion criteria: 1. Open contacts between the affected teeth. 2. Missing anterior teeth. 3. Smokers 4. Pregnant or breastfeeding females 5. Patients with systemic diseases. 6. Diastema 7. Patients with poor oral hygiene 8. Patients who take any medications known to cause gingival enlargement, gingival fillers previously done, teeth with caries, proximal restorations, fixed or orthodontic appliances. 9. Patients who had a periodontal surgeries six months prior to selection. 10. Severe periodontal bone loss.

Design outcomes

Primary

Measure	Time frame
To evaluate and compare the effectiveness and outcome of injectable platelet rich fibrin versus autologous fibrin glue versus hyaluronic acid gel in the treatment of maxillary and mandibular interdental papillary deficiencies both clinically and photographically.Timepoint: To evaluate and compare the effectiveness and outcome of injectable platelet rich fibrin versus autologous fibrin glue versus hyaluronic acid gel in the treatment of maxillary and mandibular interdental papillary deficiencies both clinically and photographically at the base line ,1 week, 1 month,3 month, 6.month	—

Measure

Time frame

To evaluate and compare the effectiveness and outcome of injectable platelet rich fibrin versus autologous fibrin glue versus hyaluronic acid gel in the treatment of maxillary and mandibular interdental papillary deficiencies both clinically and photographically.Timepoint: To evaluate and compare the effectiveness and outcome of injectable platelet rich fibrin versus autologous fibrin glue versus hyaluronic acid gel in the treatment of maxillary and mandibular interdental papillary deficiencies both clinically and photographically at the base line ,1 week, 1 month,3 month, 6.month

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Secondary

Measure	Time frame
To evaluate the effectiveness and clinical outcome of the injectable -platelet rich fibrin injection in treatment of maxillary and mandibular interdental papillary deficiency. To evaluate the effectiveness and clinical outcome of the autologous fibrin glue injection in treatment of maxillary and mandibular interdental papillary deficiency. To evaluate the effectiveness and clinical outcome of the hyaluronic acid gel injection in the treatment of maxillary and mandibular interdental papillary deficiency. To photographically evaluate and compare the improvement in black space in the interdental area followed by local injection of Injectable Platelet Rich Fibrin and Autologous fibrin glue, Hyaluronic acid gel using image J software Timepoint: base line ,1 week , 1 month , 3month,6 month.	—

Measure

Time frame

To evaluate the effectiveness and clinical outcome of the injectable -platelet rich fibrin injection in treatment of maxillary and mandibular interdental papillary deficiency. To evaluate the effectiveness and clinical outcome of the autologous fibrin glue injection in treatment of maxillary and mandibular interdental papillary deficiency. To evaluate the effectiveness and clinical outcome of the hyaluronic acid gel injection in the treatment of maxillary and mandibular interdental papillary deficiency. To photographically evaluate and compare the improvement in black space in the interdental area followed by local injection of Injectable Platelet Rich Fibrin and Autologous fibrin glue, Hyaluronic acid gel using image J software Timepoint: base line ,1 week , 1 month , 3month,6 month.

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Countries

India

Contacts

Public ContactAnjali Devi Patel

Faculty of dental sciences, IMS, BHU,Varanasi

drsarita6@gmail.com8004925677

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026