A clinical trial to study the clinical efficacy of 3 different protocols for disinfection of the root canals according to temperature in reducing postoperative pain after a root canal treatment done in a single day

Comparative clinical evaluation of Postoperative Pain using 3% Cryotreated Hypochlorite and 0.9% Cryotreated Normal Saline against Conventional root canal treated groups in patients with Symptomatic Irreversible Pulpitis/ Apical Periodontitis after single visit root canal treatment: A Randomized Clinical Study - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/07/091406

Enrollment

Registered

2025-07-22

Start date

Unknown

Completion date

Unknown

Last updated

2025-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K040- Pulpitis

Interventions

Intervention1: 3% Cryotreated Hypochlorite: 3% Sodium Hypochlorite irrigant at 2 C 4 C along with passive ultasonic irrigation Intervention2: 0.9% Cryotreated Normal Saline: 0.9% Normal Saline irrigan

Eligibility

Inclusion criteria

Inclusion criteria: 1. Healthy patient who will give informed consent will be included. 2. Single rooted teeth with completely matured root diagnosed with symptomatic irreversible pulpitis / apical periodontitis will be included. 3. Teeth with Peri Apical Index score 2 will be included in the study

Exclusion criteria

Exclusion criteria: 1. Teeth with immature roots, those diagnosed with pulp necrosis, cracks, internal/external root resorption or pulp canal obliteration and exhibiting clinical and/or radiographic signs of chronic/severe periodontitis or periapical abscess will be excluded. 2. Patients taking antibiotics, sedatives or analgesics before 24 hrs. of treatment will be excluded. 3. Teeth with previously endodontic treatment will be excluded. 4. Patients with severe periodontitis and poor oral hygiene will be excluded from the study. 5. Pregnant or lactating women will be excluded.

Design outcomes

Primary

Measure	Time frame
Postoperative painTimepoint: 6 hours , 24 hours , 48 hours , 72 hours	—

Secondary

Measure	Time frame
NILTimepoint: NIL	—

Countries

India

Contacts

Public ContactDr Aditi Goel

K.M Shah Dental College and Hospital

nshah7873@gmail.com9998994299

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026