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A Study Comparing the Effectiveness of Three Root Canal Disinfectants in Killing Bacteria During Dental Treatment

Quantitative Analysis Of Antibacterial Efficacy Of Octenidine Dihydrochloride, Sodium Hypochlorite and Chlorhexidine Digluconate against Endodontic Microflora: An In-Vivo Study - NIL

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/07/091399
Enrollment
30
Registered
2025-07-22
Start date
Unknown
Completion date
Unknown
Last updated
2026-03-30

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K041- Necrosis of pulp

Interventions

Intervention1: Octenidine dihydrochloride: Octenidine Dihydrochloride is a widely recognized disinfectant in the medical field and has been assessed in numerous in-vitro studies as a potential root ca

Sponsors

Debopratim Panja
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patient with age group of 18 to 50 years Single root teeth with fully formed root apices. Cases of non-vital asymptomatic apical periodontitis. No history of previous endodontic treatment on the desired tooth Patients who have not been under any antibiotic medications in last 3 months.

Exclusion criteria

Exclusion criteria: Medically compromised patients, with the exception of those with hypertension, well-controlled diabetes mellitus, or a history of myocardial infarction without an episode in the past six months. Re treatment endodontic cases Grossly mutilated tooth Calcified canals Tooth with wide or open apex Patients who serve on antibiotic medications during the last 3 months.

Design outcomes

Primary

MeasureTime frame
To evaluate and compare the antimicrobial efficacy of three root canal irrigants Octenidine dihydrochloride, Sodium hypochlorite, and Chlorhexidine digluconate against endodontic microflora.Timepoint: At baseline

Secondary

MeasureTime frame
To determine the microbial load in root canals before & after treatment with each irrigant using the colony-forming unit (CFU) method. Timepoint: At baseline

Countries

India

Contacts

Public ContactDebopratim Panja

Guru nanak institute of dental sciences and research

priti.desai@gnidsr.ac.in9831071632

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Apr 4, 2026