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Development of a diagnostic tool using saliva for early detection of oral precancer and oral cancer.

Development of a novel non-invasive diagnostic tool using saliva for early detection of oral submucous fibrosis and oral squamous cell carcinoma. - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2025/07/091366
Enrollment
135
Registered
2025-07-22
Start date
Unknown
Completion date
Unknown
Last updated
2025-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: C00-C14- Malignant neoplasms of lip, oral cavity and pharynx

Interventions

Intervention1: Nil: Nil Intervention2: Nil: Nil Intervention3: Nil: Nil

Sponsors

Individual Dr Pushpak Shah
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.Patients of OSMF and Oral Squamous cell carcinoma in the Age range of 25 45 years old individuals 2.Individuals of both the genders will be included 3.Individuals with history of smokeless Tobacco arecanut chewers will be included 4.Normal individuals who do not have any tobacco and areca nut habit history 5.Clinically diagnosed cases of OSMF based on clinical staging and mouth opening1. 6.Clinically diagnosed and histopathologically confirmed cases of OSCC

Exclusion criteria

Exclusion criteria: 1.Patients undergoing treatment for OSMF and OSCC. 2.Individuals with smoking history 3.Individuals with systemic illness

Design outcomes

Primary

MeasureTime frame
Identifying candidate biomarkers in saliva for early diagnosis, evaluate the progression, predict malignant transformation in OSMF and early diagnosis of Oral cancer which can help develop non invasive and rapid point of care tool for routine screening of these patients. This has public health implication in screening and early diagnosis of oral cancer . It will also help in stratifying the patients as per the disease progression and implement personalized treatment strategies. Timepoint: 2 years

Secondary

MeasureTime frame
NilTimepoint: Nil

Countries

India

Contacts

Public ContactPunnya V Angadi

Department of Oral Pathology and Microbiology, KLE VK Institute of Dental Sciences, KLE Academy of Higher Education and Research, Belgaum

punnyasanjay@gmail.com9880845530

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026