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Effect of slow breathing exercises along with usual treatment on heart rate and symptoms in patients suffering from postural orthostatic tachycardia syndrome

Effect of Resonance Frequency Paced Breathing as an Adjuvant to Standard Treatment on Heart Rate and Cardiac Autonomic Parameters in Patients with Postural Orthostatic Tachycardia Syndrome: A Randomized Controlled Trial - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/07/091338
Enrollment
28
Registered
2025-07-21
Start date
Unknown
Completion date
Unknown
Last updated
2025-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: G909- Disorder of the autonomic nervoussystem, unspecified

Interventions

Intervention1: Resonance frequency paced breathing intervention: Participants will perform resonance frequency paced breathing for 20 minutes twice a day in the morning and evening, 6 days per week, f

Sponsors

AIIMS Patna
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. All subjects were diagnosed with POTS by an experienced physician, based on the following parameters: a. Sustained increase in HR of equals to or more than 30 beats/min (within the first 10 min of HUT) in the absence of orthostatic hypotension. b. Orthostatic complaints for at least 3 months that ameliorated on return to the supine position. 2. Able to provide informed consent and adhere to the intervention schedule. 3. No prior training in resonance frequency breathing techniques.

Exclusion criteria

Exclusion criteria: 1. Presence of other cardiovascular, neurological, or psychiatric conditions 2. Current use of medications that significantly affect symptoms 3. Pregnancy or lactation 4. Cardiac pacemakers, severe heart failure or any other cardiovascular abnormality 5. Moderate to severe sensorimotor polyneuropathy 6. Neurodegenerative diseases 7. Uncontrolled Diabetes mellitus 8. Drug abuse 9. Anemia 10. Untreated hyperthyroidism 11. Prolonged bed rest

Design outcomes

Primary

MeasureTime frame
Change in heart rate response during the tilt table test (with and without resonance paced breathing). Mean HR Maximum HR Minimum HRTimepoint: At Baseline After 2 Weeks After 4 Weeks (Termination of Intervention) After 6 Weeks—

Secondary

MeasureTime frame
1. Changes in HRV parameters 2. Classical Autonomic Function Tests 3. Changes in POTS symptoms as assessed by validated questionnaireTimepoint: 1-14 Months: Patient recruitment and baseline data collection 2-16 Months: Intervention Phase 3-18 Months: Post Intervention Assessment 13-20 Months: Data Analysis 21-24 Months: Report Writing, Manuscript preparation and Dissemination of findings—

Countries

India

Contacts

Public ContactDr Raihan Mannan

All India Institute of Medical Sciences Patna

dr.raihan11456@aiimspatna.org8218225643

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026