Health Condition 1: G968- Other specified disorders of central nervous system
Conditions
Interventions
Intervention1: Nil: Nil
Intervention2: Nil: Nil
Sponsors
Rajeeb Kumar Mishra
Eligibility
Inclusion criteria
Inclusion criteria: Age of 18-70 years patients diagnosed with aSAH admitted to the hospital
Exclusion criteria
Exclusion criteria: 1.Refusal to consent 2.Ictus (event of rupture of aneurysm) more than 3 weeks old
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Quantification of the microvascular injury markers such as syndecan-1, heparan sulfate, matrix metalloproteinases (MMP), glypican-1, ICAM, sVCAM in the phases of early brain injury (EBI) and delayed cerebral ischemia (DCI) and their correlation with the occurrence of DCI and cerebral vasospasmTimepoint: Day_0, Day_2, Day_4, Day_7 | — |
Secondary
| Measure | Time frame |
|---|---|
| Correlation of syndecan-1 and HS with MMP in both phases of EBI and DCITimepoint: Day_0, Day_2, Day_4, Day_7;To correlate the syndecan-1, heparan sulfate with the World Federation of Neurosurgical Societies (WFNS) grade and modified Fisher grade at presentationTimepoint: Day_0;To study the correlation of the plasma levels of syndecan-1, HS at admission and day-7 with the Glasgow outcome scale (GOS) at 3 months following aSAH.Timepoint: Day_0, Day_7 | — |
Countries
India
Contacts
Public ContactDr Rajeeb Kumar Mishra
National Institute of Mental health and Neurosciences
Outcome results
None listed