Effect of two medicines used to increase blood pressure, phenylephrine and norepinephrine, on ability to form blood clot during caesarean delivery in patients who are thought to bleed more

Comparison of effect of phenylephrine and norepinephrine on coagulation during caesarean section in parturients at high risk of postpartum haemorrhage : a randomised, double blind study - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/07/091307

Enrollment

Registered

2025-07-21

Start date

Unknown

Completion date

Unknown

Last updated

2025-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O82- Encounter for cesarean delivery without indication Health Condition 2: 1- Obstetrics

Interventions

Intervention1: Norepinephrine infusion: Norepinephrine 4 microg per ml continuous infusion will be started IV immediately after spinal injection and then titrated based on systolic blood pressure unt

Eligibility

Inclusion criteria

Inclusion criteria: Consenting mothers scheduled to undergo caesarean section under spinal anaesthesia with at least one of the following conditions: Maternal age more than 35 years Fetal malpresentation Abnormal placenta Previous uterine surgery Uterine distension Previous history of PPH Multiple pregnancy Uterine anomaly (Fibroid)

Exclusion criteria

Exclusion criteria: History suggestive of bleeding or coagulation disorders Use of anticoagulants or antiplatelet agents within 7 days of surgery History suggestive of Infection, fever, or chorioamnionitis at time of delivery Intrauterine death Patients on monoamine oxidase inhibitors or tricyclic antidepressants History suggestive of Presence of mesenteric or peripheral vascular thrombosis Patients with absolute or relative contraindications for spinal anaesthesia Previous history suggestive of thromboembolism and deep venous thrombosis Hypertensive disorders of pregnancy Known case of Antiphospholipid antibody syndrome, Systemic lupus erythematosus, autoimmune disorders Assisted reproductive technology pregnancy

Design outcomes

Primary

Measure	Time frame
Blood loss with prophylactic infusion of phenylephrine and norepinephrine in patients undergoing caesarean section under spinal anaesthesiaTimepoint: Intraoperative and 24 hours postoperative	—

Secondary

Measure	Time frame
1) Changes in haemoglobin levels 2) Coagulation parameters 3) Requirement of uterotonics 4) Requirement of blood transfusion 5) Complications, if anyTimepoint: Intraoperative and 24 hours postoperative	—

Countries

India

Contacts

Public ContactDr Pooja

University College of Medical Sciences and Guru Teg Bahadur Hospital

mmohta@ucms.ac.in9868399626

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026