Comparing the Effects of Spinal Anesthesia With Only Bupivacaine and With Bupivacaine Plus Morphine in Women Having a C-Section

A COMPARATIVE STUDY OF SUCCEDENT VERSUS CONTROL INTRATHECAL ADMINSTRATION OF 0.5% HEAVY BUPIVACAINE WITH OR WITHOUT MORPHINE IN SPINAL BLOCK FOR CAESAREAN SECTION - nil

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2025/07/091293

Enrollment

208

Registered

2025-07-21

Start date

Unknown

Completion date

Unknown

Last updated

2025-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O82- Encounter for cesarean delivery without indication

Interventions

Intervention1: intrathecal drug administration: GROUP I (n =52) Hyperbaric bupivacaine (0.5%) 8.5mg (1.8m1) + morphine 200 mcg (0.2m1) as a mixture GROUP II (n =52) Hyperbaric bupivacaine (0.5%)

Eligibility

Inclusion criteria

Inclusion criteria: 208 healthy full term non labouring parturients, ASA I -II (American Society of Anaesthesiologists Physical status grading system), with singleton pregnancy scheduled for both elective and caesarean (CS) under SAB are included in the study .

Exclusion criteria

Exclusion criteria: 1. Complicated pregnancy 2. Multiple pregnancy 3. Pregnancy with bleeding disorders, spinal deformity, any other contraindication to SAB 4. Pregnancy with acute fetal distress 5. Intrauterine deaths or known fetal anomaly 6. Severe PIH (Pregnancy Induced Hypertension)

Design outcomes

Primary

Measure	Time frame
To compare the block characteristics among the groups.Timepoint: The time of sensory block height and maximal cephalad height and onset of motor block and regression time will be noted.	—

Secondary

Measure	Time frame
To compare the maternal hemodynamic and any intra-op and post-op complications among the groups.Timepoint: vitals will be monitored every 2 min for 20 mins and every 5 mins after 20 mins until 75 mins.;To compare the VAS score and any additional analgesia requirement among the groups Timepoint: VAS score will be assessed postoperatively at 2hr, 4hr, 12hr, 24 hr, then every day for a week.;To compare the neonatal outcome among the groups. Timepoint: APGAR score will be assessed at 1min, 5min, 10min.	—

Measure

Time frame

To compare the maternal hemodynamic and any intra-op and post-op complications among the groups.Timepoint: vitals will be monitored every 2 min for 20 mins and every 5 mins after 20 mins until 75 mins.;To compare the VAS score and any additional analgesia requirement among the groups Timepoint: VAS score will be assessed postoperatively at 2hr, 4hr, 12hr, 24 hr, then every day for a week.;To compare the neonatal outcome among the groups. Timepoint: APGAR score will be assessed at 1min, 5min, 10min.

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Countries

India

Contacts

Public ContactDr AK SINHA

Government medical college, haldwani

sinhaak1961@gmail.com9897672301

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026