Health Condition 1: O- Medical and Surgical
Conditions
Interventions
Intervention1: Nebulised Dexmedetomidine: Each patient will receive 4mL nebulised Dexmedetomidine (1mcg/kg) over 10 minutes, 40 minutes prior to surgery.
Control Intervention1: Nebulised Lignocaine: E
Sponsors
UCMS and GTB Hospital
Eligibility
Inclusion criteria
Inclusion criteria: 1. Consenting male or female patients aged 18-60 years, ASA I or ASA II scheduled for surgery under general anaesthesia.
Exclusion criteria
Exclusion criteria: 1. Patients with anticipated difficult airway 2. Any patient with history of ischemic heart disease, uncontrolled hypertension, cardiac blocks or any other contraindication for the use of dexmedetomidine 3. Patients sensitive to lignocaine
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare the SBP immediately after intubation in Group D (Dexmedetomidine) versus Group L (Lignocaine)Timepoint: Immediately after intubation | — |
Secondary
| Measure | Time frame |
|---|---|
| To compare between the two groups: 1. Systolic blood pressure(SBP) at 2 minutes and 5 minutes after intubation. 2. Diastolic blood pressure(DBP), mean arterial pressure(MAP) and heart rate(HR) at baseline and at intubation, 2 minutes and 5 minutes after intubation. 3. Consumption of propofol for induction of anaesthesia. Timepoint: 2 minutes and 5 minutes after intubation;To compare between the two group: 1. Salivary alpha amylase levels at baseline and 5 minutes post intubation 2. Serum cortisol levels at baseline and 5 minutes post intubation.Timepoint: Pre- operative and 5 minutes after intubation;To compare between the two groups: 1. Sedation in post operative period 30 minutes after extubation.Timepoint: Post operative | — |
Countries
India
Contacts
Public ContactDr Saumya Bhanot
UCMS and GTB Hospital
Outcome results
None listed