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Best Treatments for White Skin Patches: A Comparison of 5 FLuorouracil application by microneedling, TCA Acid, and Cryotherapy (Freezing Method)

A comparative study of efficacy of 5-Fluorouracil (5-FU), 50% Trichloroacetic acid (TCA) and Cryotherapy in treating patients with Idiopathic Guttate Hypomelanosis (IGH): a pilot study - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2025/07/091232
Enrollment
150
Registered
2025-07-21
Start date
Unknown
Completion date
Unknown
Last updated
2025-08-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: 5-Flurouracil(5-FU): Patients having IGH lesions distributed over various sites of body will be included in the study. 150 patients will be included in the study after considering vario

Sponsors

Dept of Dermatology th floor INHS Asvini Colaba Mumbai Maharashtra
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Clinically and dermoscopically confirmed cases with Minimum 3 IGH lesions of similar extent on body.

Exclusion criteria

Exclusion criteria: 1. Patients not giving informed consent. 2. Patients with unrealistic expectations 3. Patients who had previous topical and surgical measures for same condition 4. Keloidal tendency, active vitiligo, papulosquamous disorders and active infections 5. Bleeding tendencies 6. Cold induced urticaria, cryoglobulinemia

Design outcomes

Primary

MeasureTime frame
Outcome of modalities such as 5-Fluorouracil, Cryotherapy and 50% Trichloroacetic acid in repigmentation of lesions of Idiopathic guttate hypomelanosis.Timepoint: Serial photographs will be taken of all patients at baseline, before starting the treatment and after 12 weeks. Pre-treatment and post-treatment photographs of same individual will be compared to assess improvement of each modality. Patient satisfaction will be recorded in the same visit.

Secondary

MeasureTime frame
Assess the side effects of each modalityTimepoint: 3 months

Countries

India

Contacts

Public ContactArchana Reddy Purumandla

Institute of Naval Medicine

archana23p@gmail.com09573583649

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Feb 4, 2026